Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 17/20 | 0.54 |
| ▸ | DDB1 | Q16531 | 7/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7883381 | 0.90 | CRBN (0.56) | CRBNDDB1 | |
| SCHEMBL16891680 | 0.84 | CRBN (0.59) | CRBNDDB1 | |
| SCHEMBL7874881 | 0.81 | CRBN (0.47) | CRBNDDB1 | |
| SCHEMBL2897645 | 0.79 | CRBN (0.65) | CRBNDDB1 | |
| SCHEMBL16887554 | 0.78 | CRBN (0.61) | CRBNDDB1 | |
| SCHEMBL29889238 | 0.77 | CRBN (0.59) | CRBNDDB1 | |
| SCHEMBL16886328 | 0.77 | CRBN (0.55) | CRBNDDB1 | |
| SCHEMBL16891860 | 0.77 | CRBN (0.55) | CRBNDDB1 | |
| SCHEMBL16886893 | 0.77 | CRBN (0.55) | CRBNDDB1 | |
| SCHEMBL1630966 | 0.76 | CRBN (0.49) | CRBNDDB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010118207-A1 | PYRAZOLO [1, 5-A] PYRIMIDINE DERIVATIVES AS MTOR INHIBITORS | SCHERING CORPORATION (US) | 2010-10-14 | — | — | WO | disclosed |