Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 5/20 | 0.42 |
| ▸ | CCR8 | P51685 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | BTK | Q06187 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7881375 | 0.99 | FAAH (0.41) | FAAHCCR8KDM4EALDH1A1 | |
| SCHEMBL7879675 | 0.91 | HRH3 (0.39) | KDM4EALDH1A1 | |
| SCHEMBL7877816 | 0.91 | HRH3 (0.41) | KDM4EALDH1A1 | |
| SCHEMBL7879812 | 0.89 | FAAH (0.40) | FAAHCCR8KDM4E | |
| SCHEMBL7878049 | 0.88 | FAAH (0.40) | FAAHCCR8KDM4E | |
| SCHEMBL7877885 | 0.88 | DYRK1A (0.36) | FAAH | |
| SCHEMBL7881146 | 0.87 | FAAH (0.42) | FAAHCCR8KDM4EBTK | |
| SCHEMBL7880854 | 0.87 | PPARG (0.40) | BTK | |
| SCHEMBL7881083 | 0.86 | FAAH (0.42) | FAAHCCR8KDM4EBTK | |
| SCHEMBL7880060 | 0.86 | CHEK1 (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6248772-B1 | HYPOTENSIVE AGENTS; ANTIARRHYTHMIA AGENTS; ANTIDIABETIC AGENTS; ANTIPROLIFERATIVE AGENTS | SUMITOMO PHARMACEUTICALS CO., LTD. (JP) | 2001-06-19 | — | — | US | disclosed |
| US-6169107-B1 | USEFUL FOR THE TREATMENT AND PREVENTION OF DISEASES CAUSED BY INCREASED SODIUM/PROTON (NA.SUP.+ /H.SUP.+) EXCHANGER ACTIVITY, FOR EXAMPLE, HYPERTENSION, ARRHYTHMIA, ANGINA PECTORIS, CARDIAC HYPERTROPHY, DIABETES MELLITUS | SUMITOMO PHARMACEUTICAL CO., LTD. (JP) | 2001-01-02 | — | — | US | disclosed |
| EP-0708091-A2 | Indoloylguanidine derivatives | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1996-04-24 | — | — | EP | disclosed |