Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARA | P10276 | 9/20 | 0.46 |
| ▸ | RARB | P10826 | 9/20 | 0.46 |
| ▸ | RARG | P13631 | 9/20 | 0.46 |
| ▸ | CYP26A1 | O43174 | 5/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | CYP26B1 | Q9NR63 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | PGR | P06401 | 1/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.41 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8348341 | 1.00 | RARA (0.46) | RARARARBRARGCYP26A1CYP3A4 | |
| SCHEMBL7884597 | 0.91 | RARA (0.47) | RARARARBRARGCYP26A1CYP3A4 | |
| SCHEMBL6429184 | 0.91 | RARB (0.57) | RARARARBRARGCYP26A1CYP3A4 | |
| SCHEMBL7881533 | 0.91 | RARB (0.57) | RARARARBRARGCYP26A1CYP3A4 | |
| SCHEMBL6429182 | 0.91 | RARB (0.57) | RARARARBRARGCYP26A1CYP3A4 | |
| SCHEMBL7876881 | 0.91 | RARB (0.57) | RARARARBRARGCYP26A1CYP3A4 | |
| SCHEMBL7884594 | 0.91 | RARA (0.47) | RARARARBRARGCYP26A1CYP3A4 | |
| SCHEMBL7876877 | 0.91 | RARB (0.57) | RARARARBRARGCYP26A1CYP3A4 | |
| SCHEMBL7876893 | 0.91 | RARB (0.57) | RARARARBRARGCYP26A1CYP3A4 | |
| SCHEMBL7876525 | 0.91 | RARB (0.57) | RARARARBRARGCYP26A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6171603-B1 | TREATING SKIN, HAIR, CARDIOVASCULAR, AUTOIMMUNE AND VISION DISORDERS; ADMINISTERING AS ANTICARCINOGENIC, ANTIDEPRESSANT,ANTIINFLAMMATORY, AND ANTIACNE AGENTS | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) | 2001-01-09 | — | — | US | claimed |
| EP-0728739-B1 | Biaromatic amide derivatives, pharmaceutical and cosmetic compositions containing them and their utilisations | CIRD GALDERMA (FR) | 1997-11-05 | — | — | EP | claimed |
| US-6171603-B1 | TREATING SKIN, HAIR, CARDIOVASCULAR, AUTOIMMUNE AND VISION DISORDERS; ADMINISTERING AS ANTICARCINOGENIC, ANTIDEPRESSANT,ANTIINFLAMMATORY, AND ANTIACNE AGENTS | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) | 2001-01-09 | — | — | US | disclosed |