Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.38 |
| ▸ | PREP | P48147 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.36 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7885177 | 1.00 | HPGD (0.48) | HPGDMEN1ALDH1A1MAPTKMT2A | |
| SCHEMBL16041071 | 0.89 | HPGD (0.55) | HPGDMEN1ALDH1A1MAPTKMT2A | |
| SCHEMBL192227 | 0.88 | MEN1 (0.58) | HPGDMEN1ALDH1A1MAPTKMT2A | |
| SCHEMBL5553211 | 0.88 | MEN1 (0.58) | HPGDMEN1ALDH1A1MAPTKMT2A | |
| SCHEMBL2789282 | 0.88 | MEN1 (0.58) | HPGDMEN1ALDH1A1MAPTKMT2A | |
| SCHEMBL15317053 | 0.86 | HPGD (0.50) | HPGDMEN1ALDH1A1MAPTKMT2A | |
| SCHEMBL10082580 | 0.86 | HPGD (0.50) | HPGDMEN1ALDH1A1MAPTKMT2A | |
| SCHEMBL525478 | 0.86 | HPGD (0.50) | HPGDMEN1ALDH1A1MAPTKMT2A | |
| SCHEMBL889059 | 0.85 | HSD17B10 (0.55) | HPGDMEN1ALDH1A1MAPTKMT2A | |
| SCHEMBL3188564 | 0.85 | HSD17B10 (0.55) | HPGDMEN1ALDH1A1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1147093-A1 | SUBSTITUTED BICYCLIC DERIVATIVES USEFUL AS ANTICANCER AGENTS | Pfizer Products Inc. (US) | 2001-10-24 | — | — | EP | disclosed |
| WO-2000044728-A1 | SUBSTITUTED BICYCLIC DERIVATIVES USEFUL AS ANTICANCER AGENTS | PFIZER PRODUCTS INC. (US) | 2000-08-03 | — | — | WO | disclosed |