Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 13/20 | 1.00 |
| ▸ | HTR2C | P28335 | 13/20 | 1.00 |
| ▸ | HTR2B | P41595 | 12/20 | 1.00 |
| ▸ | PNMT | P11086 | 6/20 | 0.75 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.75 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.75 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.75 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30139643 | 0.86 | HTR2A (0.75) | HTR2AHTR2CHTR2BPNMTADRA2A | |
| SCHEMBL6187756 | 0.86 | HTR2A (0.75) | HTR2AHTR2CHTR2BPNMTADRA2A | |
| SCHEMBL1772370 | 0.86 | PNMT (1.00) | HTR2AHTR2CHTR2BPNMTADRA2A | |
| Hydrochloric Acid SCHEMBL11211829 | 0.84 | PNMT (1.00) | HTR2AHTR2CHTR2BPNMTADRA2A | |
| Hydrochloric Acid SCHEMBL11359434 | 0.84 | PNMT (0.73) | HTR2AHTR2CHTR2BPNMTADRA2A | |
| SCHEMBL10227459 | 0.80 | HTR2A (0.67) | HTR2AHTR2CHTR2BPNMTADRA2A | |
| SCHEMBL10228373 | 0.80 | HTR2C (0.67) | HTR2AHTR2CHTR2BPNMTADRA2A | |
| SCHEMBL11947505 | 0.80 | HTR2C (0.67) | HTR2AHTR2CHTR2BPNMTADRA2A | |
| SCHEMBL21762550 | 0.76 | HTR2C (1.00) | HTR2AHTR2CHTR2BPNMTADRA2A | |
| SCHEMBL10879871 | 0.75 | PNMT (0.75) | HTR2AHTR2CHTR2BPNMTADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6172073-B1 | BENZIMIDAZOLYLOXY ALKANAMINES AS SEROTONIN REUPTAKE INHIBITORS; NICOTINE AND TOBACCO WITHDRAWAL; PSYCHOLOGICAL, EATING, BRAIN, GASTROINTESTINAL, SLEEP, AND SEXUAL DISORDERS | ELI LILLY AND COMPANY | 2001-01-09 | — | — | US | disclosed |
| US-5789402-A | Compounds having effects on serotonin-related systems | ELI LILLY COMPANY (US) | 1998-08-04 | — | — | US | disclosed |
| US-5741789-A | HETERO-OXY ALKANAMINES | ELI LILLY AND COMPANY (US) | 1998-04-21 | — | — | US | disclosed |
| US-5627196-A | ANTIDEPRESSANTS AND ANTISEROTONIN AGENTS | ELI LILLY AND COMPANY (US) | 1997-05-06 | — | — | US | disclosed |
| US-5614523-A | INDOLYLOXY COMPOUNDS | ELI LILLY AND COMPANY (US) | 1997-03-25 | — | — | US | disclosed |
| US-5576321-A | ALKOXY-SUBSTITUTED INDOLES | ELI LILLY AND COMPANY (US) | 1996-11-19 | — | — | US | disclosed |
| EP-0722941-A2 | Compounds having effects on serotonin-related systems | ELI LILLY AND COMPANY (US) | 1996-07-24 | — | — | EP | disclosed |