Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | OPRM1 | P35372 | 5/20 | 0.47 |
| ▸ | OPRK1 | P41145 | 5/20 | 0.47 |
| ▸ | OPRL1 | P41146 | 5/20 | 0.47 |
| ▸ | OPRD1 | P41143 | 4/20 | 0.47 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.45 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA4 | P22748 | 1/20 | 0.40 |
| ▸ | CA5A | P35218 | 1/20 | 0.40 |
| ▸ | CA7 | P43166 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.40 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.40 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7887827 | 1.00 | SMN1; SMN2 (0.48) | SMN1; SMN2OPRM1OPRK1OPRL1OPRD1 | |
| SCHEMBL7886369 | 1.00 | SMN1; SMN2 (0.48) | SMN1; SMN2OPRM1OPRK1OPRL1OPRD1 | |
| SCHEMBL7878565 | 0.93 | CHRNA7 (0.49) | SMN1; SMN2OPRM1OPRK1OPRL1OPRD1 | |
| SCHEMBL7878435 | 0.93 | CHRNA7 (0.49) | SMN1; SMN2OPRM1OPRK1OPRL1OPRD1 | |
| SCHEMBL7014225 | 0.89 | SMN1; SMN2 (0.43) | SMN1; SMN2OPRM1OPRK1OPRL1OPRD1 | |
| SCHEMBL7007700 | 0.82 | OPRL1 (0.54) | SMN1; SMN2OPRM1OPRK1OPRL1OPRD1 | |
| SCHEMBL7015691 | 0.80 | OPRL1 (0.49) | SMN1; SMN2OPRM1OPRK1OPRL1OPRD1 | |
| SCHEMBL7889657 | 0.80 | OPRL1 (0.49) | SMN1; SMN2OPRM1OPRK1OPRL1OPRD1 | |
| SCHEMBL7885705 | 0.80 | OPRL1 (0.49) | SMN1; SMN2OPRM1OPRK1OPRL1OPRD1 | |
| SCHEMBL7887916 | 0.77 | SMN1; SMN2 (0.52) | SMN1; SMN2CA12CA1CA2CA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0856514-B1 | 8-substituted-1,3,8-triazaspiro[4.5]decan-4-on derivatives | HOFFMANN LA ROCHE (CH) | 2001-06-13 | — | — | EP | disclosed |
| US-6071925-A | ANTIDEPRESSANTS, ANTICONVULSANTS OR ANTIANXIETY AGENTS, ALSO FOR TREATMENT OF MEMORY LOSS IN ALZHEIMER'S DISEASE | HOFFMANN-LA ROCHE INC. (US) | 2000-06-06 | — | — | US | disclosed |
| EP-0856514-A1 | 8-substituted-1,3,8-triazaspiro[4.5]decan-4-on derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1998-08-05 | — | — | EP | disclosed |