Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 3/20 | 0.50 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.43 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.43 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.43 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.43 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.43 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.43 |
| ▸ | TRPM5 | Q9NZQ8 | 1/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.31 |
| ▸ | OPRL1 | P41146 | 3/20 | 0.31 |
| ▸ | HTR2A | P28223 | 3/20 | 0.31 |
| ▸ | HTR2C | P28335 | 2/20 | 0.31 |
| ▸ | HTR2B | P41595 | 2/20 | 0.31 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6031015 | 0.82 | HRH1 (0.50) | HRH1OPRK1MAPK1 | |
| SCHEMBL6031358 | 0.76 | HRH1 (0.50) | HRH1OPRK1HTR2AHTR2CHTR2B | |
| Fumaric Acid SCHEMBL6439646 | 0.75 | HRH1 (0.65) | HRH1OPRL1HTR2AHTR2CHTR2B | |
| Fumaric Acid SCHEMBL7893815 | 0.75 | HRH1 (0.65) | HRH1OPRL1HTR2AHTR2CHTR2B | |
| SCHEMBL6440008 | 0.71 | HRH1 (0.80) | HRH1HTR2AHTR2CHTR2BSIGMAR1 | |
| SCHEMBL6030115 | 0.70 | HRH1 (0.51) | HRH1OPRK1MAPK1 | |
| Water SCHEMBL6031226 | 0.70 | HRH1 (0.78) | HRH1HTR2AHTR2CHTR2BSIGMAR1 | |
| SCHEMBL6031058 | 0.70 | SIGMAR1 (0.52) | HRH1HTR2AHTR2CHTR2BSIGMAR1 | |
| SCHEMBL6031742 | 0.69 | HRH1 (0.56) | HRH1OPRK1 | |
| SCHEMBL6031453 | 0.69 | HRH1 (0.67) | HRH1OPRK1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1144411-A1 | ANTIHISTAMINIC SPIRO COMPOUNDS | Janssen Pharmaceutica N.V. (BE) | 2001-10-17 | — | — | EP | disclosed |
| WO-2000037470-A1 | ANTIHISTAMINIC SPIRO COMPOUNDS | JANSSEN PHARMACEUTICA N.V. (BE) | 2000-06-29 | — | — | WO | disclosed |