Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP3 | P42574 | 9/20 | 0.62 |
| ▸ | CASP7 | P55210 | 8/20 | 0.60 |
| ▸ | CASP1 | P29466 | 5/20 | 0.60 |
| ▸ | CTSK | P43235 | 3/20 | 0.46 |
| ▸ | CTSB | P07858 | 2/20 | 0.46 |
| ▸ | CASP9 | P55211 | 3/20 | 0.45 |
| ▸ | CASP4 | P49662 | 2/20 | 0.45 |
| ▸ | CASP10 | Q92851 | 2/20 | 0.45 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.45 |
| ▸ | CTSL | P07711 | 1/20 | 0.41 |
| ▸ | ELANE | P08246 | 1/20 | 0.41 |
| ▸ | REN | P00797 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7882928 | 0.94 | CASP3 (0.70) | CASP3CASP7CASP1CTSKCTSB | |
| SCHEMBL9962246 | 0.92 | CASP3 (0.69) | CASP3CASP7CASP1CTSKCTSB | |
| SCHEMBL7887265 | 0.92 | CASP3 (0.61) | CASP3CASP7CASP1CTSKCTSB | |
| SCHEMBL18471338 | 0.92 | CASP3 (0.61) | CASP3CASP7CASP1CTSKCTSB | |
| SCHEMBL9961904 | 0.92 | CASP3 (0.61) | CASP3CASP7CASP1CTSKCTSB | |
| SCHEMBL7889695 | 0.90 | CASP3 (0.65) | CASP3CASP7CASP1CTSKCTSB | |
| SCHEMBL7887362 | 0.85 | CASP3 (0.61) | CASP3CASP7CASP1CTSKCTSB | |
| SCHEMBL9962261 | 0.85 | CASP3 (0.53) | CASP3CASP7CASP1CTSKCTSB | |
| SCHEMBL9962171 | 0.83 | CASP3 (0.74) | CASP3CASP7CASP1CTSKCTSB | |
| SCHEMBL9961955 | 0.83 | CASP3 (0.89) | CASP3CASP7CASP1CASP9CASP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9045524-B2 | Selective caspase inhibitors and uses thereof | NOVAGENESIS FOUNDATION (CH) | 2015-06-02 | — | — | US | disclosed |
| WO-2010133000-A1 | SELECTIVE CASPASE INHIBITORS AND USES THEREOF | NEW WORLD LABORATORIES INC. (CA) | 2010-11-25 | — | — | WO | disclosed |