Cyclomethyltryptophan

Cyclomethyltryptophan

SCHEMBL7889282

O=C(O)[C@H]1Cc2c([nH]c3ccccc23)CN1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 4/20 0.71
CYP2D6 P10635 4/20 0.71
CYP1A2 P05177 2/20 0.71
CYP2C9 P11712 2/20 0.71
CYP2C19 P33261 2/20 0.71
HSD17B10 Q99714 2/20 0.71
ALDH1A1 P00352 2/20 0.71
MAPT P10636 2/20 0.71
HPGD P15428 2/20 0.71
GAA P10253 1/20 0.71
ALOX15 P16050 1/20 0.71
MAPK1 P28482 2/20 0.64
TRPM8 Q7Z2W7 1/20 0.59
TSHR P16473 1/20 0.57
MEN1 O00255 1/20 0.56
KMT2A Q03164 1/20 0.56
CYP19A1 P11511 1/20 0.50
MAPKAPK2 P49137 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Cyclomethyltryptophan SCHEMBL416557 1.00 KDM4E (0.71) KDM4ECYP2D6CYP1A2CYP2C9CYP2C19
Cyclomethyltryptophan SCHEMBL416558 1.00 KDM4E (0.71) KDM4ECYP2D6CYP1A2CYP2C9CYP2C19
Cyclomethyltryptophan SCHEMBL29535380 1.00 KDM4E (0.71) KDM4ECYP2D6CYP1A2CYP2C9CYP2C19
Cyclomethyltryptophan SCHEMBL10642614 0.98 KDM4E (0.69) KDM4ECYP2D6CYP1A2CYP2C9CYP2C19
Cyclomethyltryptophan SCHEMBL28419799 0.98 KDM4E (0.69) KDM4ECYP2D6CYP1A2CYP2C9CYP2C19
SCHEMBL12257169 0.90 CYP2D6 (0.58) KDM4ECYP2D6CYP1A2CYP2C9CYP2C19
SCHEMBL10639172 0.87 KDM4E (0.69) KDM4ECYP2D6CYP1A2CYP2C9CYP2C19
SCHEMBL1877421 0.87 KDM4E (0.69) KDM4ECYP2D6CYP1A2CYP2C9CYP2C19
SCHEMBL3110230 0.87 KDM4E (0.73) KDM4ECYP2D6CYP1A2CYP2C9CYP2C19
SCHEMBL13840607 0.87 KDM4E (0.73) KDM4ECYP2D6CYP1A2CYP2C9CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 61 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4627079-A2 THERMOSTABLE BINDING SCAFFOLDS Nectagen, Inc. (US) 2025-10-08 EP disclosed
US-20250222146-A1 Radiopharmaceuticals Targeting Somatostatin Receptor 2 and Uses Thereof RAYZEBIO, INC. (US) 2025-07-10 US disclosed
WO-2025137441-A1 RADIOPHARMACEUTICALS TARGETING SOMATOSTATIN RECEPTOR 2 AND USES THEREOF RAYZEBIO, INC. (US) 2025-06-26 WO disclosed
WO-2025137443-A1 RADIOPHARMACEUTICAL COMPOSITIONS TARGETING SOMATOSTATIN RECEPTORS AND USES THEREOF RAYZEBIO, INC. (US) 2025-06-26 WO disclosed
EP-4551563-A2 FC CONJUGATES INCLUDING AN INHIBITOR OF CD73 AND USES THEREOF CIDARA THERAPEUTICS, INC. (US) 2025-05-14 EP disclosed
CN-119816487-A FC conjugates comprising CD73 inhibitors and uses thereof 奇达拉治疗公司 2025-04-11 CN disclosed
WO-2025064788-A2 CCR5 CONJUGATES AND USES THEREOF CIDARA THERAPEUTICS, INC. (US) 2025-03-27 WO disclosed
CN-114980933-B Compositions and methods for treating viral infections 奇达拉治疗公司 2025-01-07 CN disclosed
CN-119053336-A Compositions and methods for treating autoimmune disorders 密执安大学评议会 2024-11-29 CN disclosed
CN-118879592-A Unnatural base pair compositions and methods of use 斯克利普斯研究所 2024-11-01 CN disclosed
WO-2006117548-A1 HYDROXAMIC ACID DERVICATIVES AS INHIBITORS OF HDAC ENZYMATIC ACTIVITY CHROMA THERAPEUTICS LTD (GB) 2006-11-09 WO disclosed
WO-2006117549-A1 ENZYME INHIBITORS CHROMA THERAPEUTICS LTD (GB) 2006-11-09 WO disclosed
US-5866587-A HYDROXAMIDE DERIVATIVES OF FUSED PIPERIDINE DERIVATIVES ADIR ET COMPAGNIE (FR) 1999-02-02 US disclosed
EP-0491943-A4 TETRAHYDROPYRIDOINDOLES AS CHOLECYSTOKININ AND GASTRIN ANTAGONISTS RORER INT HOLDINGS (US) 1996-02-14 EP disclosed
US-5162336-A Disorders of gastrointestinal, central nervous and appetite regulatory systems RHONE-POULENC RORER PHARMACEUTICALS INC. (US) 1992-11-10 US disclosed
EP-0491943-A1 TETRAHYDROPYRIDOINDOLES AS CHOLECYSTOKININ AND GASTRIN ANTAGONISTS RHONE-POULENC RORER INTERNATIONAL (HOLDINGS) INC. (US) 1992-07-01 EP disclosed
WO-1992000295-A1 TETRAHYDROPYRIDOINDOLES AS CHOLECYSTOKININ AND GASTRIN ANTAGONISTS RHONE-POULENC RORER INTERNATIONAL (HOLDINGS) INC. (US) 1992-01-09 WO disclosed
EP-0145304-B1 TETRAHYDRO-BETA-CARBOLINE DERIVATIVES AND PROCESS FOR THE PREPARATION THEREOF Tanabe Seiyaku Co., Ltd. (JP) 1988-04-20 EP disclosed
US-4628057-A Tetrahydro-β-carboline derivatives and treatment of liver diseases TANABE SEIYAKU CO., LTD. (JP) 1986-12-09 US disclosed
EP-0145304-A1 Tetrahydro-beta-carboline derivatives and process for the preparation thereof Tanabe Seiyaku Co., Ltd. (JP) 1985-06-19 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250222146-A1 Radiopharmaceuticals Targeting Somatostatin Receptor 2 and Uses Thereof SSTR2, SSTR4, SSTR5 KDM4E 3869/4885CYP2D6 3307/4885CYP1A2 4655/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.