Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 2/20 | 0.54 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.54 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.45 |
| ▸ | HTR1A | P08908 | 2/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.44 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.44 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4102786 | 1.00 | CHRNB2 (0.54) | CHRNB2CHRNA4PRKCZHTR1ASLC6A2 | |
| SCHEMBL759186 | 0.88 | HRH1 (0.52) | CHRNB2CHRNA4HTR1ASLC6A2IRAK4 | |
| Hydrochloric Acid SCHEMBL4105363 | 0.87 | CHRNB2 (0.55) | CHRNB2CHRNA4HTR1ASLC6A2CHRM1 | |
| Hydrochloric Acid SCHEMBL4103704 | 0.87 | CHRNB2 (0.55) | CHRNB2CHRNA4HTR1ASLC6A2CHRM1 | |
| Hydrochloric Acid SCHEMBL4713264 | 0.86 | HRH1 (0.50) | CHRNB2CHRNA4HTR1ASLC6A2IRAK4 | |
| Hydrochloric Acid SCHEMBL2447452 | 0.86 | HRH1 (0.50) | CHRNB2CHRNA4HTR1ASLC6A2IRAK4 | |
| Trifluoroacetic Acid SCHEMBL2994521 | 0.85 | CHRNB2 (0.43) | CHRNB2CHRNA4PRKCZHTR1ASLC6A2 | |
| SCHEMBL2264567 | 0.84 | SLC6A2 (0.40) | CHRNB2CHRNA4HTR1ASLC6A2CHRM1 | |
| Hydrochloric Acid SCHEMBL14861614 | 0.82 | SLC6A4 (0.39) | CHRNB2CHRNA4HTR1ASLC6A2CHRM1 | |
| SCHEMBL23830992 | 0.80 | CHRNB2 (0.46) | CHRNB2CHRNA4PRKCZHTR1ASLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140088081-A1 | Amino-Heterocyclic Compounds | PFIZER INC. (US) | 2014-03-27 | — | — | US | disclosed |
| US-20140088081-A1 | Amino-Heterocyclic Compounds | PFIZER INC. (US) | 2014-03-27 | — | — | US | disclosed |
| EP-2389382-B1 | Amino-heterocyclic compounds used as pde9 inhibitors | PFIZER (US) | 2013-06-05 | — | — | EP | disclosed |
| US-20120329777-A1 | Amino-Heterocyclic Compounds | PFIZER INC. | 2012-12-27 | — | — | US | disclosed |
| US-20120329777-A1 | Amino-Heterocyclic Compounds | PFIZER INC. | 2012-12-27 | — | — | US | disclosed |
| US-8278295-B2 | Amino-heterocyclic compounds | PFIZER INC. (US) | 2012-10-02 | — | — | US | disclosed |
| US-8278295-B2 | Amino-heterocyclic compounds | PFIZER INC. (US) | 2012-10-02 | — | — | US | disclosed |
| US-20100190771-A1 | AMINO-HETEROCYCLIC COMPOUNDS | PFIZER INC. | 2010-07-29 | — | — | US | disclosed |
| US-20100190771-A1 | AMINO-HETEROCYCLIC COMPOUNDS | PFIZER INC. | 2010-07-29 | — | — | US | disclosed |
| WO-2010084438-A1 | AMINO-HETEROCYCLIC COMPOUNDS USED AS PDE9 INHIBITORS | PFIZER INC. (US) | 2010-07-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120329777-A1 | Amino-Heterocyclic Compounds | PDE9A, PDE2A, PDE10A | CHRNB2 170/4885CHRNA4 161/4885PRKCZ 257/4885 |
| US-20100190771-A1 | AMINO-HETEROCYCLIC COMPOUNDS | PDE9A, PDE2A, PDE10A | CHRNB2 170/4885CHRNA4 161/4885PRKCZ 257/4885 |
| US-20140088081-A1 | Amino-Heterocyclic Compounds | PDE9A, PDE2A, PDE10A | CHRNB2 170/4885CHRNA4 161/4885PRKCZ 257/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.