Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 1/20 | 0.45 |
| ▸ | OPRM1 | P35372 | 15/20 | 0.45 |
| ▸ | OPRL1 | P41146 | 15/20 | 0.45 |
| ▸ | OPRK1 | P41145 | 14/20 | 0.45 |
| ▸ | OPRD1 | P41143 | 6/20 | 0.45 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.42 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.42 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.41 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.41 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7883594 | 0.88 | OPRL1 (0.52) | OPRM1OPRL1OPRK1OPRD1 | |
| SCHEMBL2245724 | 0.88 | OPRL1 (0.52) | OPRM1OPRL1OPRK1OPRD1 | |
| SCHEMBL550293 | 0.88 | OPRL1 (0.52) | OPRM1OPRL1OPRK1OPRD1 | |
| SCHEMBL7878453 | 0.83 | CHRNA7 (0.65) | CHRNA7OPRM1OPRL1OPRK1OPRD1 | |
| SCHEMBL7878773 | 0.83 | CHRNA7 (0.65) | CHRNA7OPRM1OPRL1OPRK1OPRD1 | |
| SCHEMBL7878455 | 0.83 | CHRNA7 (0.65) | CHRNA7OPRM1OPRL1OPRK1OPRD1 | |
| SCHEMBL30077049 | 0.83 | CHRNA7 (0.65) | CHRNA7OPRM1OPRL1OPRK1OPRD1 | |
| SCHEMBL30077103 | 0.83 | CHRNA7 (0.65) | CHRNA7OPRM1OPRL1OPRK1OPRD1 | |
| SCHEMBL7886593 | 0.79 | OPRM1 (0.43) | CHRNA7OPRM1OPRL1OPRK1OPRD1 | |
| Hydrochloric Acid SCHEMBL7878644 | 0.74 | OPRL1 (0.51) | OPRM1OPRL1OPRK1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0856514-B1 | 8-substituted-1,3,8-triazaspiro[4.5]decan-4-on derivatives | HOFFMANN LA ROCHE (CH) | 2001-06-13 | — | — | EP | disclosed |
| US-6071925-A | ANTIDEPRESSANTS, ANTICONVULSANTS OR ANTIANXIETY AGENTS, ALSO FOR TREATMENT OF MEMORY LOSS IN ALZHEIMER'S DISEASE | HOFFMANN-LA ROCHE INC. (US) | 2000-06-06 | — | — | US | disclosed |
| CN-1191862-A | 8-substituted-1,3,8-triaza-spiro [4,5] decan-4-on derivatives | HOFFMANN LA ROCHE (CH) | 1998-09-02 | — | — | CN | disclosed |
| EP-0856514-A1 | 8-substituted-1,3,8-triazaspiro[4.5]decan-4-on derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1998-08-05 | — | — | EP | disclosed |