SCHEMBL7889755

SCHEMBL7889755

CCOC(=O)c1cc(-c2c(O)cc(OCOC)cc2Oc2ccc([N+](=O)[O-])cc2)no1

nearest known ligand 0.51

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
HSP90AA1 P07900 9/20 0.51
HSP90AB1 P08238 7/20 0.47
MAPT P10636 5/20 0.41
MAOB P27338 1/20 0.40
KDM4E B2RXH2 2/20 0.39
MEN1 O00255 1/20 0.39
POLB P06746 1/20 0.39
KMT2A Q03164 1/20 0.39
USP10 Q14694 1/20 0.37
PTPN11 Q06124 1/20 0.37
MAPK1 P28482 1/20 0.37
NPSR1 Q6W5P4 1/20 0.37
TDP1 Q9NUW8 1/20 0.37
AR P10275 1/20 0.37
GAA P10253 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL658319 0.93 HSP90AA1 (0.43) HSP90AA1HSP90AB1MAPTMAOBKDM4E
SCHEMBL656598 0.89 HSP90AA1 (0.62) HSP90AA1HSP90AB1MAPTMAOBKDM4E
SCHEMBL7893392 0.88 HSP90AA1 (0.40) HSP90AA1HSP90AB1MAPTKDM4EMEN1
SCHEMBL7892419 0.86 HSP90AA1 (0.50) HSP90AA1HSP90AB1MAPTKDM4ENPSR1
SCHEMBL7885618 0.85 HSP90AA1 (0.61) HSP90AA1HSP90AB1MAPTMAOBGAA
SCHEMBL657005 0.84 HSP90AA1 (0.46) HSP90AA1HSP90AB1MAPTMAOBMEN1
SCHEMBL7898075 0.83 HSP90AA1 (0.44) HSP90AA1HSP90AB1MAPTMAOBTDP1
SCHEMBL657051 0.83 MAOB (0.46) HSP90AA1HSP90AB1MAPTMAOBKDM4E
SCHEMBL656890 0.81 LMNA (0.38) HSP90AA1MAPTKDM4EMEN1KMT2A
SCHEMBL656515 0.80 HSP90AA1 (0.51) HSP90AA1HSP90AB1MAPTMAOBGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2010121963-A1 RESORCINOL DERIVATIVES AS HSP90 INHIBITORS NERVIANO MEDICAL SCIENCES S.R.L. (IT) 2010-10-28 WO disclosed