SCHEMBL7889779

SCHEMBL7889779

Cc1c(C(=O)O)oc2cccc(OC(N)(CCF)Cc3cccnc3)c12

nearest known ligand 0.51

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
NMT2 O60551 13/20 0.51
NMT1 P30419 13/20 0.51
EDNRA P25101 2/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7892997 0.87 NMT2 (0.46) NMT2NMT1
SCHEMBL7889833 0.84 NMT2 (0.41) NMT2NMT1
SCHEMBL3619906 0.77 EDNRA (0.76) NMT2NMT1EDNRA
SCHEMBL3472011 0.75 NMT2 (0.83) NMT2NMT1
SCHEMBL7889761 0.72 EDNRA (0.50) NMT2NMT1EDNRA
SCHEMBL7889764 0.72 NMT2 (0.56) NMT2NMT1EDNRA
SCHEMBL7041979 0.68 NMT2 (0.81) NMT2NMT1
SCHEMBL6868005 0.68 NMT2 (0.53) NMT2NMT1EDNRA
SCHEMBL3620721 0.67 NMT2 (0.58) NMT2NMT1EDNRA
SCHEMBL3472871 0.67 NMT2 (1.00) NMT2NMT1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1149094-A2 4-(AMINOALKOXY)BENZOFURANS AS N-MYRISTOYLTRANSFERASE INHIBITORS Basilea Pharmaceutica AG (CH) 2001-10-31 EP disclosed
WO-2000037464-A2 4-(AMINOALKOXY)BENZOFURANS AS N-MYRISTOYLTRANSFERASE INHIBITORS BASILEA PHARMACEUTICA AG (CH) 2000-06-29 WO disclosed