Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.66 |
| ▸ | NPC1 | O15118 | 4/20 | 0.56 |
| ▸ | RAB9A | P51151 | 4/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.56 |
| ▸ | TP53 | P04637 | 3/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.49 |
| ▸ | RBP4 | P02753 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16178505 | 0.87 | RAB9A (0.57) | POLBNPC1RAB9ASMN1; SMN2TP53 | |
| SCHEMBL23951569 | 0.87 | POLB (0.55) | POLBNPC1RAB9ASMN1; SMN2TP53 | |
| SCHEMBL16178748 | 0.83 | POLB (0.46) | POLBNPC1RAB9ASMN1; SMN2TSHR | |
| SCHEMBL16178759 | 0.83 | NPC1 (0.60) | POLBNPC1RAB9ASMN1; SMN2TP53 | |
| SCHEMBL6716470 | 0.83 | MAPT (0.65) | NPC1RAB9ASMN1; SMN2CYP1A2CYP2D6 | |
| SCHEMBL30965841 | 0.83 | CNR2 (0.53) | HPGDGRIN2B | |
| SCHEMBL16178483 | 0.82 | HTT (0.65) | POLBNPC1RAB9ASMN1; SMN2TSHR | |
| SCHEMBL5193941 | 0.82 | POLB (0.57) | POLBNPC1RAB9ASMN1; SMN2TP53 | |
| SCHEMBL16178734 | 0.81 | GAA (0.60) | POLBRAB9ASMN1; SMN2ALDH1A1HTT | |
| SCHEMBL656655 | 0.81 | POLB (0.97) | POLBNPC1RAB9ASMN1; SMN2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010102663-A1 | PIPERAZINE DERIVATIVES FOR USE IN THERAPY | GLAXO GROUP LIMITED (GB) | 2010-09-16 | — | — | WO | disclosed |