Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.47 |
| ▸ | ACACB | O00763 | 1/20 | 0.46 |
| ▸ | BCHE | P06276 | 2/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.44 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.41 |
| ▸ | LTA4H | P09960 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | FUCA1 | P04066 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7891487 | 0.87 | MCHR1 (0.47) | MCHR1KDM4EKMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL27546385 | 0.81 | EPHX2 (0.54) | ACACBKDM4EKMT2AEPHX2LTA4H | |
| SCHEMBL7899149 | 0.81 | EPHX2 (0.54) | ACACBKDM4EKMT2AEPHX2LTA4H | |
| SCHEMBL7899607 | 0.80 | ACACB (0.49) | HRH3ACACBMCHR1KDM4ESMN1; SMN2 | |
| SCHEMBL7898015 | 0.79 | KDM4E (0.54) | HRH3BCHESIGMAR1KDM4EKMT2A | |
| SCHEMBL7891518 | 0.78 | BCHE (0.45) | HRH3ACACBBCHESIGMAR1KDM4E | |
| SCHEMBL7891512 | 0.78 | BCHE (0.45) | HRH3ACACBBCHESIGMAR1KDM4E | |
| SCHEMBL5689925 | 0.77 | BCHE (0.47) | HRH3BCHESIGMAR1KDM4EKMT2A | |
| SCHEMBL7902701 | 0.75 | FOXM1 (0.53) | HRH3BCHEKDM4EKMT2ASMN1; SMN2 | |
| SCHEMBL27473865 | 0.73 | HRH3 (0.54) | HRH3ACACBMCHR1KDM4EKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6184236-B1 | Method of treating a neurodegenerative disease by administering an aryl-cyclohexylamine derivative | HOFFMANN-LA ROCHE INC. | 2001-02-06 | — | — | US | disclosed |
| EP-0982026-A2 | Use of aryl-cyclohexylamine derivatives in the manufacture of NMDA receptor blockers | F. HOFFMANN-LA ROCHE AG (CH) | 2000-03-01 | — | — | EP | disclosed |