Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | BCHE | P06276 | 2/20 | 0.52 |
| ▸ | GRIN2B | Q13224 | 8/20 | 0.51 |
| ▸ | FOXM1 | Q08050 | 1/20 | 0.50 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.46 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.46 |
| ▸ | LTA4H | P09960 | 1/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7902701 | 0.92 | FOXM1 (0.53) | KDM4EKMT2ASMN1; SMN2BCHEGRIN2B | |
| SCHEMBL7900897 | 0.85 | GRIN2B (0.59) | SMN1; SMN2GRIN2BGRIN1SIGMAR1 | |
| SCHEMBL7899612 | 0.83 | GRIN2B (0.61) | KMT2AGRIN2BGRIN1SIGMAR1SLC6A2 | |
| SCHEMBL7899005 | 0.82 | ME3 (0.60) | SMN1; SMN2GRIN2BGRIN1SIGMAR1SLC6A2 | |
| SCHEMBL5689918 | 0.81 | KDM4E (0.56) | KDM4EKMT2ASMN1; SMN2BCHEGRIN2B | |
| SCHEMBL5690423 | 0.81 | KDM4E (0.56) | KDM4EKMT2ASMN1; SMN2BCHEGRIN2B | |
| SCHEMBL5689916 | 0.81 | KDM4E (0.56) | KDM4EKMT2ASMN1; SMN2BCHEGRIN2B | |
| SCHEMBL7899165 | 0.80 | ME3 (0.58) | LTA4HEPHX2 | |
| SCHEMBL7891504 | 0.79 | HRH3 (0.47) | KDM4EKMT2ASMN1; SMN2BCHESLC2A1 | |
| SCHEMBL7891512 | 0.78 | BCHE (0.45) | KDM4EKMT2ASMN1; SMN2BCHESLC2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1141936-C | Usage of aryl-cyclohexylamine derivant in anti-disturbance of central nervous system | - | 2004-03-17 | — | — | CN | disclosed |
| US-6184236-B1 | Method of treating a neurodegenerative disease by administering an aryl-cyclohexylamine derivative | HOFFMANN-LA ROCHE INC. | 2001-02-06 | — | — | US | disclosed |
| CN-1248439-A | Usage of aryl-cyclohexylamine derivant in anti-disturbance of central nervous system | HOFFMAN LA ROCHE & CO AKTEINGE (DE) | 2000-03-29 | — | — | CN | disclosed |
| EP-0982026-A2 | Use of aryl-cyclohexylamine derivatives in the manufacture of NMDA receptor blockers | F. HOFFMANN-LA ROCHE AG (CH) | 2000-03-01 | — | — | EP | disclosed |