Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | TSHR | P16473 | 3/20 | 0.52 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.47 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | CCR5 | P51681 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | APAF1 | O14727 | 1/20 | 0.40 |
| ▸ | NSD2 | O96028 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | GALK1 | P51570 | 1/20 | 0.40 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7894560 | 1.00 | KMT2A (0.53) | KMT2AMEN1TSHRAKR1C3AKR1C1 | |
| SCHEMBL7894311 | 1.00 | KMT2A (0.53) | KMT2AMEN1TSHRAKR1C3AKR1C1 | |
| SCHEMBL7894562 | 1.00 | KMT2A (0.53) | KMT2AMEN1TSHRAKR1C3AKR1C1 | |
| SCHEMBL7894303 | 1.00 | KMT2A (0.53) | KMT2AMEN1TSHRAKR1C3AKR1C1 | |
| SCHEMBL25229338 | 0.91 | CYP2C19 (0.46) | KMT2AMEN1TSHRAKR1C3AKR1C1 | |
| SCHEMBL10935105 | 0.91 | CYP2C19 (0.46) | KMT2AMEN1TSHRAKR1C3AKR1C1 | |
| SCHEMBL17592878 | 0.90 | KMT2A (0.63) | KMT2AMEN1TSHRAKR1C3AKR1C1 | |
| SCHEMBL17592875 | 0.90 | KMT2A (0.63) | KMT2AMEN1TSHRAKR1C3AKR1C1 | |
| SCHEMBL19734569 | 0.88 | KMT2A (0.47) | KMT2AMEN1TSHRAKR1C3AKR1C1 | |
| SCHEMBL17374190 | 0.88 | KMT2A (0.47) | KMT2AMEN1TSHRAKR1C3AKR1C1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6180611-B1 | INHIBITORS OF MATRIX METALLOPROTEINASES AND TUMOR NECROSIS FACTOR | DARWIN DISCOVERY, LTD. (GB) | 2001-01-30 | — | — | US | disclosed |
| US-5994312-A | Peptidyl compounds | DARWIN DISCOVERY, LTD. (GB) | 1999-11-30 | — | — | US | disclosed |
| CN-1193978-A | Peptidyl compounds and their therapeutic use as inhibitors of metalloproteases | CHIROSCIENCE LTD (GB) | 1998-09-23 | — | — | CN | disclosed |