SCHEMBL19734569

SCHEMBL19734569

O=C(O)C1CC(N2C(=O)c3ccccc3C2=O)C1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 3/20 0.47
MEN1 O00255 1/20 0.47
TSHR P16473 3/20 0.46
L3MBTL1 Q9Y468 1/20 0.46
CA12 O43570 1/20 0.42
CA9 Q16790 1/20 0.42
LMNA P02545 1/20 0.41
GAA P10253 1/20 0.41
CCR5 P51681 1/20 0.41
CYP2C19 P33261 1/20 0.41
APAF1 O14727 1/20 0.40
NSD2 O96028 1/20 0.40
POLB P06746 1/20 0.40
MAPT P10636 1/20 0.40
THRB P10828 1/20 0.40
CASP3 P42574 1/20 0.40
RECQL P46063 1/20 0.40
GALK1 P51570 1/20 0.40
HKDC1 Q2TB90 1/20 0.40
SENP8 Q96LD8 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17374190 1.00 KMT2A (0.47) KMT2AMEN1TSHRL3MBTL1CA12
SCHEMBL17374189 1.00 KMT2A (0.47) KMT2AMEN1TSHRL3MBTL1CA12
SCHEMBL19742113 1.00 KMT2A (0.47) KMT2AMEN1TSHRL3MBTL1CA12
SCHEMBL7894299 0.88 KMT2A (0.53) KMT2AMEN1TSHRL3MBTL1CA12
SCHEMBL7894303 0.88 KMT2A (0.53) KMT2AMEN1TSHRL3MBTL1CA12
SCHEMBL7894560 0.88 KMT2A (0.53) KMT2AMEN1TSHRL3MBTL1CA12
SCHEMBL7894311 0.88 KMT2A (0.53) KMT2AMEN1TSHRL3MBTL1CA12
SCHEMBL7894562 0.88 KMT2A (0.53) KMT2AMEN1TSHRL3MBTL1CA12
SCHEMBL25229338 0.85 CYP2C19 (0.46) KMT2AMEN1TSHRL3MBTL1LMNA
SCHEMBL10935105 0.85 CYP2C19 (0.46) KMT2AMEN1TSHRL3MBTL1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11203586-B2 Iridinesulfonamide compound and use method thereof CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD. (CN) 2021-12-21 US disclosed
US-20210369749-A1 COMPOUNDS, COMPOSITIONS, AND METHODS FOR INCREASING CFTR ACTIVITY PROTEOSTASIS THERAPEUTICS INC (US) 2021-12-02 US disclosed
US-20210155610-A1 Iridinesulfonamide Compound And Use Method Thereof LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD. (CN) 2021-05-27 US disclosed
EP-3444237-B1 IRIDINESULFONAMIDE COMPOUND AND USE METHOD THEREOF CHIA TAI TIANQING PHARMACEUTICAL GROUP CO LTD (CN) 2020-10-28 EP disclosed
US-10738040-B2 Compounds, compositions, and methods for increasing CFTR activity PROTEOSTASIS THERAPEUTICS, INC. (US) 2020-08-11 US disclosed
US-10738040-B2 Compounds, compositions, and methods for increasing CFTR activity PROTEOSTASIS THERAPEUTICS, INC. (US) 2020-08-11 US disclosed
US-20200190072-A1 COMPOUNDS, COMPOSITIONS, AND METHODS FOR INCREASING CFTR ACTIVITY PROTEOSTASIS THERAPEUTICS, INC. 2020-06-18 US disclosed
EP-3157917-B1 COMPOUNDS, COMPOSITIONS AND METHODS OF INCREASING CFTR ACTIVITY PROTEOSTASIS THERAPEUTICS INC (US) 2020-03-18 EP disclosed
US-20190308960-A1 COMPOUNDS, COMPOSITIONS, AND METHODS FOR INCREASING CFTR ACTIVITY PROTEOSTASIS THERAPEUTICS, INC. 2019-10-10 US disclosed
US-20190308960-A1 COMPOUNDS, COMPOSITIONS, AND METHODS FOR INCREASING CFTR ACTIVITY PROTEOSTASIS THERAPEUTICS, INC. 2019-10-10 US disclosed
WO-2017162156-A1 IRIDINESULFONAMIDE COMPOUND AND USE METHOD THEREOF 正大天晴药业集团股份有限公司 2017-09-28 WO disclosed
US-20170233379-A1 COMPOUNDS, COMPOSITIONS, AND METHODS FOR INCREASING CFTR ACTIVITY PROTEOSTASIS THERAPEUTICS, INC. 2017-08-17 US disclosed
US-20170233379-A1 COMPOUNDS, COMPOSITIONS, AND METHODS FOR INCREASING CFTR ACTIVITY PROTEOSTASIS THERAPEUTICS, INC. 2017-08-17 US disclosed
US-20170233379-A1 COMPOUNDS, COMPOSITIONS, AND METHODS FOR INCREASING CFTR ACTIVITY PROTEOSTASIS THERAPEUTICS, INC. 2017-08-17 US disclosed
EP-3157917-A1 COMPOUNDS, COMPOSITIONS AND METHODS OF INCREASING CFTR ACTIVITY Proteostasis Therapeutics, Inc. (US) 2017-04-26 EP disclosed
WO-2017040606-A1 ISOXAZOLE DERIVATIVES FOR USE IN THE TREATMENT OF PULMONARY DISEASES AND DISORDERS PROTEOSTASIS THERAPEUTICS, INC. (US) 2017-03-09 WO disclosed
WO-2016115090-A1 COMPOUNDS, COMPOSITIONS AND METHODS FOR INCREASING CFTR ACTIVITY PROTEOSTASIS THERAPEUTICS, INC. (US) 2016-07-21 WO disclosed
WO-2015196071-A9 COMPOUNDS, COMPOSITIONS AND METHODS OF INCREASING CFTR ACTIVITY PROTEOSTASIS THERAPEUTICS, INC. (US) 2016-02-18 WO disclosed
WO-2015196071-A1 COMPOUNDS, COMPOSITIONS AND METHODS OF INCREASING CFTR ACTIVITY PROTEOSTASIS THERAPEUTICS, INC. (US) 2015-12-23 WO disclosed
WO-2015196071-A1 COMPOUNDS, COMPOSITIONS AND METHODS OF INCREASING CFTR ACTIVITY PROTEOSTASIS THERAPEUTICS, INC. (US) 2015-12-23 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210369749-A1 COMPOUNDS, COMPOSITIONS, AND METHODS FOR INCREASING CFTR ACTIVITY CFTR, ABCB4, ATP5ME KMT2A 4759/4885MEN1 4330/4885TSHR 4373/4885
US-20190308960-A1 COMPOUNDS, COMPOSITIONS, AND METHODS FOR INCREASING CFTR ACTIVITY CFTR, ABCB4, SCNN1B KMT2A 4776/4885MEN1 4749/4885TSHR 4373/4885
US-11203586-B2 Iridinesulfonamide compound and use method thereof IDH1, IDH3B, IDH3A KMT2A 808/4885MEN1 285/4885TSHR 4638/4885
US-20170233379-A1 COMPOUNDS, COMPOSITIONS, AND METHODS FOR INCREASING CFTR ACTIVITY CFTR, ABCB4, SCNN1B KMT2A 4776/4885MEN1 4749/4885TSHR 4373/4885
US-20210155610-A1 Iridinesulfonamide Compound And Use Method Thereof IDH1, IDH3B, IDH3A KMT2A 808/4885MEN1 285/4885TSHR 4638/4885
US-20200190072-A1 COMPOUNDS, COMPOSITIONS, AND METHODS FOR INCREASING CFTR ACTIVITY CFTR, SCNN1B, SCNN1G KMT2A 4753/4885MEN1 4638/4885TSHR 3833/4885
US-10738040-B2 Compounds, compositions, and methods for increasing CFTR activity CFTR, ABCB4, SCNN1B KMT2A 4776/4885MEN1 4749/4885TSHR 4373/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.