Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 2/20 | 0.56 |
| ▸ | MMP1 | P03956 | 12/20 | 0.55 |
| ▸ | MMP2 | P08253 | 9/20 | 0.55 |
| ▸ | MMP3 | P08254 | 8/20 | 0.55 |
| ▸ | MMP8 | P22894 | 8/20 | 0.54 |
| ▸ | MMP9 | P14780 | 5/20 | 0.54 |
| ▸ | MMP7 | P09237 | 4/20 | 0.54 |
| ▸ | FCER2 | P06734 | 1/20 | 0.54 |
| ▸ | PSMB5 | P28074 | 3/20 | 0.51 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.50 |
| ▸ | ACE | P12821 | 1/20 | 0.50 |
| ▸ | CPA1 | P15085 | 1/20 | 0.50 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.50 |
| ▸ | MMP12 | P39900 | 1/20 | 0.50 |
| ▸ | MMP13 | P45452 | 1/20 | 0.50 |
| ▸ | MMP14 | P50281 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7895350 | 0.92 | MME (0.56) | MMEMMP1MMP2MMP3MMP8 | |
| SCHEMBL7426252 | 0.90 | MMP1 (0.62) | MMEMMP1MMP2MMP3MMP8 | |
| SCHEMBL7383157 | 0.90 | MMP1 (0.62) | MMEMMP1MMP2MMP3MMP8 | |
| SCHEMBL6413299 | 0.90 | MMP1 (0.62) | MMEMMP1MMP2MMP3MMP8 | |
| SCHEMBL7424246 | 0.90 | MMP1 (0.62) | MMEMMP1MMP2MMP3MMP8 | |
| SCHEMBL7428922 | 0.87 | MMP1 (0.63) | MMEMMP1MMP2MMP3MMP8 | |
| SCHEMBL6419589 | 0.87 | MMP1 (0.63) | MMEMMP1MMP2MMP3MMP8 | |
| SCHEMBL7382552 | 0.87 | MMP1 (0.63) | MMEMMP1MMP2MMP3MMP8 | |
| SCHEMBL6417820 | 0.86 | MME (0.61) | MMEMMP1MMP2MMP3MMP8 | |
| SCHEMBL6418586 | 0.86 | MME (0.61) | MMEMMP1MMP2MMP3MMP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6180611-B1 | INHIBITORS OF MATRIX METALLOPROTEINASES AND TUMOR NECROSIS FACTOR | DARWIN DISCOVERY, LTD. (GB) | 2001-01-30 | — | — | US | disclosed |