SCHEMBL7896416

SCHEMBL7896416

CN(C(=O)/C=C/CC1(N)CCC1)C(Cc1ccc2ccccc2c1)C(=O)N(C)C(Cc1ccccc1)C(=O)N1CCC(O)CC1

nearest known ligand 0.52

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
GHSR Q92847 7/20 0.45
OPRD1 P41143 1/20 0.41
F2 P00734 1/20 0.39
TACR1 P25103 3/20 0.37
CYP51A1 Q16850 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL867607 1.00 GHSR (0.45) GHSROPRD1F2TACR1CYP51A1
SCHEMBL867608 1.00 GHSR (0.45) GHSROPRD1F2TACR1CYP51A1
SCHEMBL10039191 0.94 GHSR (0.46) GHSROPRD1TACR1
SCHEMBL867613 0.93 GHSR (0.44) GHSROPRD1TACR1
SCHEMBL867612 0.93 GHSR (0.44) GHSROPRD1TACR1
SCHEMBL13752317 0.93 GHSR (0.44) GHSROPRD1TACR1
SCHEMBL10039198 0.93 GHSR (0.44) GHSROPRD1TACR1
SCHEMBL1401016 0.91 GHSR (0.46) GHSROPRD1TACR1
SCHEMBL1401013 0.91 GHSR (0.46) GHSROPRD1TACR1
SCHEMBL867706 0.91 GHSR (0.40) GHSROPRD1F2CYP51A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1100824-A1 COMPOUNDS WITH GROWTH HORMONE RELEASING PROPERTIES NOVO NORDISK A/S (DK) 2001-05-23 EP disclosed
WO-2000001726-A1 COMPOUNDS WITH GROWTH HORMONE RELEASING PROPERTIES NOVO NORDISK A/S (DK) 2000-01-13 WO disclosed