Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MC4R | P32245 | 5/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | RAF1 | P04049 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.35 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
| ▸ | ACP3 | P15309 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7898964 | 0.97 | KEAP1 (0.44) | KEAP1MAPK1NPC1MEN1PLA2G1B | |
| SCHEMBL5793141 | 0.97 | KEAP1 (0.44) | KEAP1MAPK1NPC1MEN1PLA2G1B | |
| SCHEMBL7896612 | 0.95 | KEAP1 (0.45) | KEAP1MAPK1NPC1MEN1PLA2G1B | |
| Hydrochloric Acid SCHEMBL17871924 | 0.88 | KEAP1 (0.39) | KEAP1MAPK1NPC1MEN1PLA2G1B | |
| SCHEMBL7895952 | 0.80 | MEN1 (0.45) | KEAP1MAPK1MEN1KMT2AGAA | |
| SCHEMBL7898810 | 0.79 | MEN1 (0.43) | KEAP1MAPK1NPC1MEN1PLA2G1B | |
| SCHEMBL7896616 | 0.79 | GAA (0.42) | KEAP1MAPK1NPC1MEN1KMT2A | |
| SCHEMBL7888872 | 0.78 | KEAP1 (0.49) | KEAP1MAPK1NPC1GAAMC4R | |
| SCHEMBL442668 | 0.77 | MC4R (0.54) | KEAP1MAPK1NPC1GAAMC4R | |
| SCHEMBL1964089 | 0.77 | MC4R (0.54) | KEAP1MAPK1NPC1GAAMC4R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE37035-E1 | HYPOGLYCEMIC AGENTS | BOEHRINGER INGELHEIM KG (DE) | 2001-01-30 | — | — | US | disclosed |
| US-6143769-A | ENANTIOMORPH | KARL THOMAE GMBH (DE) | 2000-11-07 | — | — | US | disclosed |
| US-5312924-A | Compounds for lowering blood sugar and effecting metabolism | DR. KARL THOMAE GMBH (DE) | 1994-05-17 | — | — | US | disclosed |
| US-5216167-A | Hypoglycemic agents | DR. KARL THOMAE GMBH (DE) | 1993-06-01 | — | — | US | disclosed |
| EP-0208200-B1 | PHENYLACETIC-ACID DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PROCESSES FOR THEIR PRODUCTION | Dr. Karl Thomae GmbH (DE) | 1990-04-25 | — | — | EP | disclosed |
| EP-0208200-A1 | Phenylacetic-acid derivatives, pharmaceutical compositions containing them and processes for their production | Dr. Karl Thomae GmbH (DE) | 1987-01-14 | — | — | EP | disclosed |