Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK8 | P49336 | 2/20 | 0.58 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.58 |
| ▸ | KDR | P35968 | 2/20 | 0.58 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.58 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.58 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.58 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.58 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.58 |
| ▸ | CSF1R | P07333 | 1/20 | 0.58 |
| ▸ | PRKACA | P17612 | 1/20 | 0.58 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.58 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.58 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.58 |
| ▸ | LIMK1 | P53667 | 2/20 | 0.47 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.47 |
| ▸ | FLT1 | P17948 | 1/20 | 0.47 |
| ▸ | CDK9 | P50750 | 1/20 | 0.47 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.42 |
| ▸ | DRD1 | P21728 | 10/20 | 0.39 |
| ▸ | FLT3 | P36888 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7972162 | 0.98 | CDK8 (0.56) | CDK8ROCK1KDRMAP2K1DYRK1A | |
| SCHEMBL31478470 | 0.76 | CDK8 (0.65) | CDK8ROCK1KDRMAP2K1DYRK1A | |
| SCHEMBL260187 | 0.74 | CDK8 (0.53) | CDK8ROCK1KDRMAP2K1DYRK1A | |
| SCHEMBL18324191 | 0.74 | CDK8 (0.53) | CDK8ROCK1KDRMAP2K1DYRK1A | |
| SCHEMBL334306 | 0.74 | CDK8 (0.53) | CDK8ROCK1KDRMAP2K1DYRK1A | |
| SCHEMBL4770221 | 0.74 | CDK8 (0.53) | CDK8ROCK1KDRMAP2K1DYRK1A | |
| SCHEMBL260258 | 0.74 | CDK8 (0.56) | CDK8ROCK1KDRMAP2K1DYRK1A | |
| SCHEMBL21352246 | 0.74 | CDK8 (0.53) | CDK8ROCK1KDRMAP2K1DYRK1A | |
| SCHEMBL22836801 | 0.74 | CDK8 (0.53) | CDK8ROCK1KDRMAP2K1DYRK1A | |
| SCHEMBL10247 | 0.74 | CDK8 (0.53) | CDK8ROCK1KDRMAP2K1DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010128995-A1 | PHENOXYMETHYL HETEROCYCLIC COMPOUNDS | ENVIVO PHARMACEUTICALS, INC. (US) | 2010-11-11 | — | — | WO | disclosed |
| US-6235731-B1 | REDUCING BLOOD LIPIDS, SUGARS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2001-05-22 | — | — | US | disclosed |
| EP-0915888-A1 | FUSED IMIDAZOPYRIDINE DERIVATIVES AS ANTIHYPERLIPIDEMIC AGENTS | Takeda Chemical Industries, Ltd. (JP) | 1999-05-19 | — | — | EP | disclosed |
| WO-1997040051-A1 | FUSED IMIDAZOPYRIDINE DERIVATIVES AS ANTIHYPERLIPIDEMIC AGENTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1997-10-30 | — | — | WO | disclosed |