Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK8 | P49336 | 2/20 | 0.53 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.53 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.53 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.53 |
| ▸ | CSF1R | P07333 | 1/20 | 0.53 |
| ▸ | PRKACA | P17612 | 1/20 | 0.53 |
| ▸ | KDR | P35968 | 1/20 | 0.53 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.53 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.53 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.53 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.53 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.53 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.53 |
| ▸ | FLT1 | P17948 | 1/20 | 0.47 |
| ▸ | CDK9 | P50750 | 1/20 | 0.47 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.47 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.47 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.42 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.36 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL2265015 | 0.98 | CDK8 (0.52) | CDK8ROCK1CHEK1MAP4K4CSF1R | |
| SCHEMBL334306 | 0.74 | CDK8 (0.53) | CDK8ROCK1CHEK1MAP4K4CSF1R | |
| SCHEMBL21352246 | 0.74 | CDK8 (0.53) | CDK8ROCK1CHEK1MAP4K4CSF1R | |
| SCHEMBL18324191 | 0.74 | CDK8 (0.53) | CDK8ROCK1CHEK1MAP4K4CSF1R | |
| SCHEMBL260258 | 0.74 | CDK8 (0.56) | CDK8ROCK1CHEK1MAP4K4CSF1R | |
| SCHEMBL260187 | 0.74 | CDK8 (0.53) | CDK8ROCK1CHEK1MAP4K4CSF1R | |
| SCHEMBL4770221 | 0.74 | CDK8 (0.53) | CDK8ROCK1CHEK1MAP4K4CSF1R | |
| SCHEMBL22836801 | 0.74 | CDK8 (0.53) | CDK8ROCK1CHEK1MAP4K4CSF1R | |
| SCHEMBL7896883 | 0.74 | CDK8 (0.58) | CDK8ROCK1CHEK1MAP4K4CSF1R | |
| SCHEMBL11537174 | 0.74 | CDK8 (0.49) | CDK8ROCK1CHEK1MAP4K4CSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 235 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260124222-A1 | ISOTHIAZOLYLCARBOXAMIDE COMPOUNDS AND THEIR USE IN THERAPY | HOTSPOT THERAPEUTICS INC (US) | 2026-05-07 | — | — | US | disclosed |
| US-20260085073-A1 | PYRAZOLYLCARBOXAMIDE COMPOUNDS AND THEIR USE IN THERAPY | HOTSPOT THERAPEUTICS INC (US) | 2026-03-26 | — | — | US | disclosed |
| US-20260027113-A1 | PHTHALAZINONE BASED MODULATORS FOR THE TREATMENT OF DISEASE | SOLEY THERAPEUTICS INC (US) | 2026-01-29 | — | — | US | disclosed |
| US-12465603-B2 | Phthalazinone based modulators for the treatment of disease | SOLEY THERAPEUTICS, INC. (US) | 2025-11-11 | — | — | US | disclosed |
| EP-4619387-A1 | PHTHALAZINONE BASED MODULATORS FOR THE TREATMENT OF DISEASE | Soley Therapeutics, Inc. (US) | 2025-09-24 | — | — | EP | disclosed |
| US-20250122171-A1 | Substituted Amine Compounds, Compositions and Methods of Use | DEEP APPLE THERAPEUTICS, INC. | 2025-04-17 | — | — | US | disclosed |
| WO-2025064534-A1 | SUBSTITUTED AMINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | DEEP APPLE THERAPEUTICS, INC. (US) | 2025-03-27 | — | — | WO | disclosed |
| US-20250026758-A1 | MUSCARINIC ACETYLCHOLINE M1 RECEPTOR ANTAGONISTS | CONTINEUM THERAPEUTICS INC (US) | 2025-01-23 | — | — | US | disclosed |
| US-20240425491-A1 | HETEROARYL COMPOUNDS USEFUL IN THE TREATMENT OF COGNITIVE DISORDERS | DRAIG THERAPEUTICS LTD (GB) | 2024-12-26 | — | — | US | disclosed |
| CN-119112895-A | Muscarinic acetylcholine M1 receptor antagonists | 康蒂内乌姆医疗公司 | 2024-12-13 | — | — | CN | disclosed |
| EP-0915888-A1 | FUSED IMIDAZOPYRIDINE DERIVATIVES AS ANTIHYPERLIPIDEMIC AGENTS | Takeda Chemical Industries, Ltd. (JP) | 1999-05-19 | — | — | EP | disclosed |
| WO-1997040051-A1 | FUSED IMIDAZOPYRIDINE DERIVATIVES AS ANTIHYPERLIPIDEMIC AGENTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1997-10-30 | — | — | WO | disclosed |
| US-4408047-A | ADRENERGIC BLOCKING | MERCK & CO., INC. (US) | 1983-10-04 | — | — | US | disclosed |
| EP-0006614-B1 | PYRIDYL- AND IMIDAZOPYRIDYLOXYPROPANOLAMINES, PROCESS FOR PREPARING THE SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME | MERCK & CO. INC. (US) | 1983-09-21 | — | — | EP | disclosed |
| US-4336261-A | IMIDAZO/1,2A/PYRIDINE, HYPOTENSIVE AGENTS | MERCK & CO., INC. (US) | 1982-06-22 | — | — | US | disclosed |
| US-4330543-A | AS ADRENERGIC BLOCKING AGENTS | MERCK & CO., INC. (US) | 1982-05-18 | — | — | US | disclosed |
| US-4233301-A | ADRENERGIC BLOCKING AGENTS | MERCK & CO., INC. (US) | 1980-11-11 | — | — | US | disclosed |
| US-4210653-A | HYPOTENSIVE AGENTS | MERCK & CO., INC. (US) | 1980-07-01 | — | — | US | disclosed |
| EP-0006614-A2 | Pyridyl- and imidazopyridyloxypropanolamines, process for preparing the same and pharmaceutical compositions containing the same | MERCK & CO. INC. (US) | 1980-01-09 | — | — | EP | disclosed |
| US-4166851-A | ADRENERGIC BLOCKING AGENTS | MERCK & CO., INC. (US) | 1979-09-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12465603-B2 | Phthalazinone based modulators for the treatment of disease | MKI67, BCL2, CCAR2 | CDK8 444/4885ROCK1 1382/4885CHEK1 1499/4885 |
| US-20260027113-A1 | PHTHALAZINONE BASED MODULATORS FOR THE TREATMENT OF DISEASE | NCOR1, NOP56, NCOR2 | CDK8 1877/4885ROCK1 592/4885CHEK1 1378/4885 |
| US-20250122171-A1 | Substituted Amine Compounds, Compositions and Methods of Use | MRGPRX2, MRGPRX1, MRGPRX4 | CDK8 3575/4885ROCK1 3365/4885CHEK1 3668/4885 |
| US-20240425491-A1 | HETEROARYL COMPOUNDS USEFUL IN THE TREATMENT OF COGNITIVE DISORDERS | GABRA5, GABRB3, GABRA3 | CDK8 4279/4885ROCK1 2345/4885CHEK1 4353/4885 |
| US-20260085073-A1 | PYRAZOLYLCARBOXAMIDE COMPOUNDS AND THEIR USE IN THERAPY | MALT1, BCL6, BCL3 | CDK8 1100/4885ROCK1 1387/4885CHEK1 3924/4885 |
| US-20250026758-A1 | MUSCARINIC ACETYLCHOLINE M1 RECEPTOR ANTAGONISTS | CHRM1, CHRM2, CHRM5 | CDK8 2468/4885ROCK1 833/4885CHEK1 1092/4885 |
| US-20260124222-A1 | ISOTHIAZOLYLCARBOXAMIDE COMPOUNDS AND THEIR USE IN THERAPY | MALT1, BCL6, BCL6B | CDK8 2155/4885ROCK1 1848/4885CHEK1 3110/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.