Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | APP | P05067 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.41 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 3/20 | 0.40 |
| ▸ | EGFR | P00533 | 2/20 | 0.40 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.40 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.40 |
| ▸ | PDE5A | O76074 | 2/20 | 0.40 |
| ▸ | CDK1 | P06493 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL789699 | 0.82 | HTT (0.56) | HTTMEN1KMT2AAPPNPC1 | |
| SCHEMBL789612 | 0.82 | MEN1 (0.44) | HTTMEN1KMT2AAPPNPC1 | |
| SCHEMBL18571730 | 0.82 | MEN1 (0.44) | HTTMEN1KMT2AAPPNPC1 | |
| SCHEMBL29523642 | 0.78 | APP (0.55) | MEN1KMT2AAPPNPC1GAA | |
| SCHEMBL2278793 | 0.78 | MEN1 (0.50) | HTTMEN1KMT2AAPPNPC1 | |
| SCHEMBL21061514 | 0.78 | EGFR (0.51) | HTTMEN1KMT2AAPPNPC1 | |
| SCHEMBL21682034 | 0.76 | MEN1 (0.42) | HTTMEN1KMT2AAPPNPC1 | |
| SCHEMBL21061613 | 0.75 | MEN1 (0.50) | HTTMEN1KMT2AAPPNPC1 | |
| SCHEMBL30589327 | 0.75 | MEN1 (0.50) | HTTMEN1KMT2AAPPNPC1 | |
| SCHEMBL21682355 | 0.75 | ALDH1A1 (0.47) | HTTMEN1KMT2AAPPNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012037108-A1 | AMINOQUINOLINE DERIVATIVES AS ANTIVIRAL AGENTS | GLAXOSMITHKLINE LLC (US) | 2012-03-22 | — | — | WO | disclosed |
| WO-2012037108-A1 | AMINOQUINOLINE DERIVATIVES AS ANTIVIRAL AGENTS | GLAXOSMITHKLINE LLC (US) | 2012-03-22 | — | — | WO | disclosed |