Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | TP53 | P04637 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7890180 | 0.93 | SMN1; SMN2 (0.57) | TSHRMAPK1SMN1; SMN2ALDH1A1TP53 | |
| SCHEMBL9829571 | 0.93 | SMN1; SMN2 (0.57) | TSHRMAPK1SMN1; SMN2ALDH1A1TP53 | |
| SCHEMBL7899963 | 0.92 | SMN1; SMN2 (0.59) | TSHRMAPK1SMN1; SMN2ALDH1A1TP53 | |
| SCHEMBL9831322 | 0.92 | SMN1; SMN2 (0.59) | TSHRMAPK1SMN1; SMN2ALDH1A1TP53 | |
| SCHEMBL9831734 | 0.89 | SMN1; SMN2 (0.50) | TSHRMAPK1SMN1; SMN2ALDH1A1TP53 | |
| SCHEMBL9830268 | 0.89 | TSHR (0.54) | TSHRMAPK1SMN1; SMN2ALDH1A1TP53 | |
| SCHEMBL9831740 | 0.89 | SMN1; SMN2 (0.50) | TSHRMAPK1SMN1; SMN2ALDH1A1TP53 | |
| SCHEMBL9830280 | 0.89 | TSHR (0.54) | TSHRMAPK1SMN1; SMN2ALDH1A1TP53 | |
| SCHEMBL23441779 | 0.88 | TP53 (0.57) | TSHRMAPK1SMN1; SMN2ALDH1A1TP53 | |
| SCHEMBL9828504 | 0.87 | TSHR (0.52) | TSHRMAPK1SMN1; SMN2ALDH1A1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6180140-B1 | SUITABLE FOR ORAL ADMINISTRATION OF BIOLOGICALLY ACTIVE AGENTS TO ANIMALS | EMISPHERE TECHNOLOGIES, INC. | 2001-01-30 | — | — | US | disclosed |
| US-5935601-A | Modified amino acids for drug delivery | EMISPHERE TECHNOLOGIES, INC. (US) | 1999-08-10 | — | — | US | disclosed |
| EP-0758843-A4 | MODIFIED AMINO ACIDS FOR DRUG DELIVERY | EMISPHERE TECH INC (US) | 1998-05-20 | — | — | EP | disclosed |
| US-5709861-A | PEPTIDES WITH ANTIGENS AND PROCESS FOR MIXING | EMISPHERE TECHNOLOGIES, INC. (US) | 1998-01-20 | — | — | US | disclosed |
| EP-0758843-A1 | MODIFIED AMINO ACIDS FOR DRUG DELIVERY | Emisphere Technologies, Inc. (US) | 1997-02-26 | — | — | EP | disclosed |
| WO-1995028838-A1 | MODIFIED AMINO ACIDS FOR DRUG DELIVERY | EMISPHERE TECHNOLOGIES, INC. (US) | 1995-11-02 | — | — | WO | disclosed |