Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | LTA4H | P09960 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | CCR1 | P32246 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9828500 | 1.00 | TSHR (0.52) | TSHRMAPK1HPGDSMN1; SMN2CYP2C19 | |
| SCHEMBL9830280 | 0.98 | TSHR (0.54) | TSHRMAPK1HPGDSMN1; SMN2CYP2C19 | |
| SCHEMBL9830268 | 0.98 | TSHR (0.54) | TSHRMAPK1HPGDSMN1; SMN2CYP2C19 | |
| SCHEMBL7898085 | 0.87 | TSHR (0.56) | TSHRMAPK1HPGDSMN1; SMN2CYP2C19 | |
| SCHEMBL7899963 | 0.84 | SMN1; SMN2 (0.59) | TSHRMAPK1HPGDSMN1; SMN2CYP2C19 | |
| SCHEMBL9831322 | 0.84 | SMN1; SMN2 (0.59) | TSHRMAPK1HPGDSMN1; SMN2CYP2C19 | |
| SCHEMBL5901288 | 0.84 | RECQL (0.50) | HPGDSMN1; SMN2LTA4HPOLBRECQL | |
| SCHEMBL6288389 | 0.84 | RECQL (0.50) | HPGDSMN1; SMN2LTA4HPOLBRECQL | |
| SCHEMBL9829571 | 0.83 | SMN1; SMN2 (0.57) | TSHRMAPK1HPGDSMN1; SMN2CYP2C19 | |
| SCHEMBL7890180 | 0.83 | SMN1; SMN2 (0.57) | TSHRMAPK1HPGDSMN1; SMN2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0226304-B1 | COMPOSITION CONTAINING A PENEM OR CARBAPENEM ANTIBIOTIC | SANKYO COMPANY LIMITED (JP) | 1991-08-28 | — | — | EP | disclosed |
| US-4757066-A | Reduces renal toxicity | SANKYO COMPANY LIMITED (JP) | 1988-07-12 | — | — | US | disclosed |
| EP-0226304-A1 | Composition containing a penem or carbapenem antibiotic | SANKYO COMPANY LIMITED (JP) | 1987-06-24 | — | — | EP | disclosed |