⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29512993 | 1.00 | — | — | |
| Fluoride Ion SCHEMBL28306558 | 0.95 | NOS3 (0.38) | — | |
| SCHEMBL12648083 | 0.81 | — | — | |
| SCHEMBL30716708 | 0.81 | — | — | |
| SCHEMBL10255501 | 0.79 | — | — | |
| SCHEMBL30828998 | 0.79 | — | — | |
| SCHEMBL259696 | 0.79 | — | — | |
| SCHEMBL1255045 | 0.77 | — | — | |
| SCHEMBL30423024 | 0.77 | — | — | |
| SCHEMBL13354601 | 0.77 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 251 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016040780-A1 | AMINOMETHYL- AND METHYLOXY-LINKED TRICYCLIC COMPOUNDS AS INHIBITORS OF PROTEIN AGGREGATION | NEUROPORE THERAPIES, INC. (US) | 2016-03-17 | — | — | WO | claimed |
| EP-2685821-A1 | NUCLEAR HORMONE RECEPTOR MODULATORS | AbbVie Inc. (US) | 2014-01-22 | — | — | EP | claimed |
| US-20120238549-A1 | Nuclear Hormone Receptor Modulators | ABBOTT LABORATORIES (US) | 2012-09-20 | — | — | US | claimed |
| WO-2012125797-A1 | NUCLEAR HORMONE RECEPTOR MODULATORS | ABBOTT LABORATORIES (US) | 2012-09-20 | — | — | WO | claimed |
| CN-102056927-A | Fused nitrogen containing heterocycles and compositions thereof as kinase inhibitors | IRM LLC | 2011-05-11 | — | — | CN | claimed |
| EP-0175263-B1 | 2-AMINO-3-CHLOROMETHYL-5-(DICHLOROMETHYL)-PYRAZINES AND PROCESS FOR THEIR PREPARATION | BASF Aktiengesellschaft (DE) | 1991-06-05 | — | — | EP | claimed |
| EP-0175263-A2 | 2-Amino-3-chloromethyl-5-(dichloromethyl)-pyrazines and process for their preparation | BASF Aktiengesellschaft (DE) | 1986-03-26 | — | — | EP | claimed |
| US-12473289-B2 | Heterocyclic compounds as delta-5 desaturase inhibitors and methods of use | AMGEN INC. (US) | 2025-11-18 | — | — | US | disclosed |
| US-12384789-B2 | Compounds for treating Huntington's disease | PTC THERAPEUTICS, INC. (US) | 2025-08-12 | — | — | US | disclosed |
| US-12139499-B2 | Heteroaryl compounds for treating Huntington's disease | PTC THERAPEUTICS, INC. (US) | 2024-11-12 | — | — | US | disclosed |
| EP-3814360-B1 | HETEROARYL COMPOUNDS FOR TREATING HUNTINGTON'S DISEASE | PTC THERAPEUTICS INC (US) | 2024-10-02 | — | — | EP | disclosed |
| EP-3814345-B1 | HETEROARYL COMPOUNDS FOR TREATING HUNTINGTON'S DISEASE | PTC THERAPEUTICS INC (US) | 2024-09-25 | — | — | EP | disclosed |
| US-12036292-B2 | Heterobiaryl compounds and imaging agents for imaging huntingtin protein | CHDI FOUNDATION, INC. (US) | 2024-07-16 | — | — | US | disclosed |
| EP-0111160-B1 | PROCESS FOR THE PREPARATION OF 2-HALOGEN AND 2-CYANO PYRAZINES | BASF Aktiengesellschaft (DE) | 1986-10-22 | — | — | EP | disclosed |
| EP-0175264-A2 | Process for the preparation of 2-amino-3-cyano-5-dialkoxymethyl pyrazines and intermediates for this process | BASF Aktiengesellschaft (DE) | 1986-03-26 | — | — | EP | disclosed |
| EP-0175263-A2 | 2-Amino-3-chloromethyl-5-(dichloromethyl)-pyrazines and process for their preparation | BASF Aktiengesellschaft (DE) | 1986-03-26 | — | — | EP | disclosed |
| EP-0175263-A2 | 2-Amino-3-chloromethyl-5-(dichloromethyl)-pyrazines and process for their preparation | BASF Aktiengesellschaft (DE) | 1986-03-26 | — | — | EP | disclosed |
| US-4560756-A | 2-Aminopyrazines and the preparation of 2-aminopyrazines and pyrazines | BASF AKTIENGESELLSCHAFT (DE) | 1985-12-24 | — | — | US | disclosed |
| EP-0111717-A2 | 2-Aminopyrazine and process for the preparation of 2-aminopyrazines and pyrazines | BASF Aktiengesellschaft (DE) | 1984-06-27 | — | — | EP | disclosed |
| EP-0111160-A1 | Process for the preparation of 2-halogen and 2-cyano pyrazines | BASF Aktiengesellschaft (DE) | 1984-06-20 | — | — | EP | disclosed |