Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Meloxicam. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 known ✓ | P35354 | 4/20 | 0.98 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.98 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.98 |
| ▸ | GLA | P06280 | 1/20 | 0.98 |
| ▸ | EDNRA | P25101 | 1/20 | 0.98 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.76 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.76 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.76 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.76 |
| ▸ | LMNA | P02545 | 2/20 | 0.76 |
| ▸ | PKM | P14618 | 2/20 | 0.76 |
| ▸ | THPO | P40225 | 1/20 | 0.76 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.76 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.62 |
| ▸ | USP2 | O75604 | 2/20 | 0.62 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.62 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.62 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.62 |
| ▸ | BLM | P54132 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Meloxicam SCHEMBL23589638 | 0.99 | PTGS1 (1.00) | PTGS1PTGS2ABCB11GLAEDNRA | |
| Meloxicam SCHEMBL3752395 | 0.99 | PTGS1 (1.00) | PTGS1PTGS2ABCB11GLAEDNRA | |
| Meloxicam SCHEMBL3576 | 0.99 | PTGS1 (1.00) | PTGS1PTGS2ABCB11GLAEDNRA | |
| Meloxicam SCHEMBL332206 | 0.98 | PTGS1 (0.98) | PTGS1PTGS2ABCB11GLAEDNRA | |
| Meloxicam SCHEMBL20168549 | 0.98 | PTGS1 (0.98) | PTGS1PTGS2ABCB11GLAEDNRA | |
| Meloxicam SCHEMBL3373822 | 0.98 | PTGS1 (0.98) | PTGS1PTGS2ABCB11GLAEDNRA | |
| Meloxicam SCHEMBL20168506 | 0.98 | PTGS1 (0.98) | PTGS1PTGS2ABCB11GLAEDNRA | |
| Meloxicam SCHEMBL2352397 | 0.98 | PTGS1 (0.98) | PTGS1PTGS2ABCB11GLAEDNRA | |
| Meloxicam SCHEMBL332632 | 0.98 | PTGS1 (0.98) | PTGS1PTGS2ABCB11GLAEDNRA | |
| Meloxicam SCHEMBL20165003 | 0.98 | PTGS1 (0.98) | PTGS1PTGS2ABCB11GLAEDNRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6284269-B1 | Pharmaceutical compositions of meloxicam with improved solubility and bioavailability | HEXAL AG (DE) | 2001-09-04 | — | — | US | disclosed |
| EP-1007049-A1 | NEW PHARMACEUTICAL COMPOSITIONS OF MELOXICAM WITH IMPROVED SOLUBILITY AND BIOAVAILABILITY | Hexal AG (DE) | 2000-06-14 | — | — | EP | disclosed |
| WO-1999009988-A1 | NEW PHARMACEUTICAL COMPOSITIONS OF MELOXICAM WITH IMPROVED SOLUBILITY AND BIOAVAILABILITY | HEXAL AG (DE) | 1999-03-04 | — | — | WO | disclosed |