Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.74 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.74 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.71 |
| ▸ | RAB9A | P51151 | 1/20 | 0.66 |
| ▸ | GAA | P10253 | 1/20 | 0.66 |
| ▸ | POLB | P06746 | 2/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.60 |
| ▸ | MEN1 | O00255 | 3/20 | 0.60 |
| ▸ | ATM | Q13315 | 1/20 | 0.59 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.42 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.41 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.41 |
| ▸ | USP7 | Q93009 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6098746 | 1.00 | SMN1; SMN2 (0.74) | SMN1; SMN2ALDH1A1TDP1RAB9AGAA | |
| SCHEMBL7898749 | 1.00 | SMN1; SMN2 (0.74) | SMN1; SMN2ALDH1A1TDP1RAB9AGAA | |
| SCHEMBL2188279 | 0.85 | ALDH1A1 (0.74) | SMN1; SMN2ALDH1A1TDP1RAB9AGAA | |
| SCHEMBL6099597 | 0.85 | ALDH1A1 (0.74) | SMN1; SMN2ALDH1A1TDP1RAB9AGAA | |
| SCHEMBL9025236 | 0.85 | ALDH1A1 (1.00) | SMN1; SMN2ALDH1A1TDP1RAB9AGAA | |
| SCHEMBL6099600 | 0.85 | ALDH1A1 (0.74) | SMN1; SMN2ALDH1A1TDP1RAB9AGAA | |
| SCHEMBL2188282 | 0.85 | ALDH1A1 (0.74) | SMN1; SMN2ALDH1A1TDP1RAB9AGAA | |
| SCHEMBL2188278 | 0.85 | ALDH1A1 (0.74) | SMN1; SMN2ALDH1A1TDP1RAB9AGAA | |
| SCHEMBL6099592 | 0.85 | ALDH1A1 (0.74) | SMN1; SMN2ALDH1A1TDP1RAB9AGAA | |
| SCHEMBL8529114 | 0.83 | TDP1 (0.73) | SMN1; SMN2ALDH1A1TDP1RAB9AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1080080-A4 | NOVEL THERAPEUTIC AGENTS THAT MODULATE NEUROKININ RECEPTORS | ADVANCED MEDICINE INC (US) | 2001-03-07 | — | — | EP | disclosed |
| EP-1080080-A1 | NOVEL THERAPEUTIC AGENTS THAT MODULATE NEUROKININ RECEPTORS | Advanced Medicine, Inc. (US) | 2001-03-07 | — | — | EP | disclosed |
| WO-1999064000-A9 | NOVEL THERAPEUTIC AGENTS THAT MODULATE NEUROKININ RECEPTORS | ADVANCED MEDICINE INC (US) | 2000-04-20 | — | — | WO | disclosed |
| WO-1999064000-A1 | NOVEL THERAPEUTIC AGENTS THAT MODULATE NEUROKININ RECEPTORS | ADVANCED MEDICINE, INC. (US) | 1999-12-16 | — | — | WO | disclosed |
| EP-0683767-B1 | AZACYCLIC COMPOUNDS, COMPOSITIONS CONTAINING THEM AND THEIR USE AS TACHYKININ ANTAGONISTS | MERCK SHARP & DOHME (GB) | 1998-06-03 | — | — | EP | disclosed |
| EP-0687268-B1 | SPIROAZACYCLIC DERIVATIVES AS SUBSTANCE P ANTAGONISTS | PFIZER (US) | 1998-05-27 | — | — | EP | disclosed |
| EP-0594636-B1 | 3-AMINOPIPERIDINE DERIVATIVES AND RELATED NITROGEN CONTAINING HETEROCYCLES | PFIZER (US) | 1998-01-21 | — | — | EP | disclosed |
| US-5633266-A | Azacyclic compounds compositions containing them and their use as tachykinin antagonists | MERCK SHARP & DOHME LTD. (GB) | 1997-05-27 | — | — | US | disclosed |
| EP-0687268-A1 | SPIROAZACYCLIC DERIVATIVES AS SUBSTANCE P ANTAGONISTS | PFIZER INC. (US) | 1995-12-20 | — | — | EP | disclosed |
| EP-0683767-A1 | AZACYCLIC COMPOUNDS, COMPOSITIONS CONTAINING THEM AND THEIR USE AS TACHYKININ ANTAGONISTS | MERCK SHARP & DOHME LTD. (GB) | 1995-11-29 | — | — | EP | disclosed |
| EP-0436334-B1 | 3-Aminopiperidine derivatives and related nitrogen containing heterocycles | PFIZER (US) | 1994-12-07 | — | — | EP | disclosed |
| WO-1994020500-A1 | SPIROAZACYCLIC DERIVATIVES AS SUBSTANCE P ANTAGONISTS | PFIZER INC. (US) | 1994-09-15 | — | — | WO | disclosed |
| WO-1994019323-A1 | AZACYCLIC COMPOUNDS, COMPOSITIONS CONTAINING THEM AND THEIR USE AS TACHYKININ ANTAGONISTS | MERCK SHARP & DOHME LIMITED (GB) | 1994-09-01 | — | — | WO | disclosed |
| US-5332817-A | 3-aminopiperidine derivatives and related nitrogen containing heterocycles | PFIZER INC. (US) | 1994-07-26 | — | — | US | disclosed |
| EP-0594636-A1 | 3-AMINOPIPERIDINE DERIVATIVES AND RELATED NITROGEN CONTAINING HETEROCYCLES | PFIZER INC. (US) | 1994-05-04 | — | — | EP | disclosed |
| US-5232929-A | 3-aminopiperidine derivatives and related nitrogen containing heterocycles and pharmaceutical compositions and use | PFIZER INC. (US) | 1993-08-03 | — | — | US | disclosed |
| WO-1993001170-A1 | 3-AMINOPIPERIDINE DERIVATIVES AND RELATED NITROGEN CONTAINING HETEROCYCLES | PFIZER INC. (US) | 1993-01-21 | — | — | WO | disclosed |
| WO-1991009844-A1 | SUBSTANCE P ANTAGONISTS | PFIZER INC. (US) | 1991-07-11 | — | — | WO | disclosed |
| EP-0436334-A2 | 3-Aminopiperidine derivatives and related nitrogen containing heterocycles | PFIZER INC. (US) | 1991-07-10 | — | — | EP | disclosed |