Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 6/20 | 0.49 |
| ▸ | LTA4H | P09960 | 5/20 | 0.49 |
| ▸ | ACACB | O00763 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.45 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | YAP1 | P46937 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7891512 | 0.81 | BCHE (0.45) | EPHX2LTA4HACACBRAB9AALDH1A1 | |
| SCHEMBL7891518 | 0.81 | BCHE (0.45) | EPHX2LTA4HACACBRAB9AALDH1A1 | |
| SCHEMBL7899149 | 0.80 | EPHX2 (0.54) | EPHX2LTA4HACACBMAPTRAB9A | |
| SCHEMBL27546385 | 0.80 | EPHX2 (0.54) | EPHX2LTA4HACACBMAPTRAB9A | |
| SCHEMBL7899165 | 0.77 | ME3 (0.58) | EPHX2LTA4HMAPTRAB9AFFAR4 | |
| SCHEMBL7891567 | 0.76 | NPC1 (0.46) | LTA4HACACBMAPTRAB9AALDH1A1 | |
| SCHEMBL7891575 | 0.76 | NPC1 (0.46) | LTA4HACACBMAPTRAB9AALDH1A1 | |
| SCHEMBL7902716 | 0.73 | TP53 (0.60) | MAPTALDH1A1 | |
| SCHEMBL7898002 | 0.73 | ME3 (0.76) | EPHX2MAPTRAB9AALDH1A1LMNA | |
| SCHEMBL20887692 | 0.71 | ACACB (0.61) | LTA4HACACBMAPTALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1141936-C | Usage of aryl-cyclohexylamine derivant in anti-disturbance of central nervous system | - | 2004-03-17 | — | — | CN | disclosed |
| US-6184236-B1 | Method of treating a neurodegenerative disease by administering an aryl-cyclohexylamine derivative | HOFFMANN-LA ROCHE INC. | 2001-02-06 | — | — | US | disclosed |
| CN-1248439-A | Usage of aryl-cyclohexylamine derivant in anti-disturbance of central nervous system | HOFFMAN LA ROCHE & CO AKTEINGE (DE) | 2000-03-29 | — | — | CN | disclosed |
| EP-0982026-A2 | Use of aryl-cyclohexylamine derivatives in the manufacture of NMDA receptor blockers | F. HOFFMANN-LA ROCHE AG (CH) | 2000-03-01 | — | — | EP | disclosed |