Sugi Predict

Sugi Predict / Targets / ME3

ME3

NADP-dependent malic enzyme, mitochondrial · Q16798 · ME3 on Sugi Atlas →

9,573 patent compounds predicted against ME3, 6,625 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL1128293 SCHEMBL1128293 0.55 7/20
SCHEMBL1977631 SCHEMBL1977631 0.52 6/20
Hydrochloric Acid Hydrochloric Acid (SCHEMBL2255585) 0.47 6/20
SCHEMBL2158309 SCHEMBL2158309 0.60 5/20
SCHEMBL2236040 SCHEMBL2236040 0.59 5/20
SCHEMBL1735467 SCHEMBL1735467 0.47 5/20
SCHEMBL1733516 SCHEMBL1733516 0.46 5/20
SCHEMBL662317 SCHEMBL662317 0.41 5/20
SCHEMBL2306481 SCHEMBL2306481 0.62 4/20
SCHEMBL1904981 SCHEMBL1904981 0.58 4/20
SCHEMBL2288557 SCHEMBL2288557 0.55 4/20
SCHEMBL1136936 SCHEMBL1136936 0.49 4/20
SCHEMBL2158310 SCHEMBL2158310 0.48 4/20
SCHEMBL110127 SCHEMBL110127 0.48 4/20
SCHEMBL1732997 SCHEMBL1732997 0.45 4/20
SCHEMBL656446 SCHEMBL656446 0.41 4/20
SCHEMBL1904828 SCHEMBL1904828 0.60 3/20
SCHEMBL945189 SCHEMBL945189 0.60 3/20
SCHEMBL2157567 SCHEMBL2157567 0.58 3/20
Hydrochloric Acid Hydrochloric Acid (SCHEMBL2309495) 0.58 3/20

Clinical trials — most relevant to ME3 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Glutamate for Metabolic Intervention in Coronary Surgery PHASE3COMPLETED
Clinical Evaluation of the Effect of Metformin in Sepsis PHASE3UNKNOWN
Acetylcarnitine and Insulin Sensitivity PHASE2COMPLETED
Efficacy of KL1333 in Adult Patients With Primary Mitochondrial Disease PHASE2RECRUITING
Nicotinamide Riboside on Mitochondrial Function in Li-Fraumeni Syndrome PHASE1/PHASE2COMPLETED
Phase 1a Single Ascending Dose Study of MIB-725 in Healthy Adults PHASE1RECRUITING
Does Clinical Treatment of Mitochondrial Dysfunction Impact Autism Spectrum Disorder (ASD)? PHASE1UNKNOWN
GDF-15 as a Biomarker for Mitochondrial Disease nanCOMPLETED
Nicotinamide Levels in Serum, Aqueous Humor, and Tear Film in Glaucoma and Correlations With Mitochondrial Damage-Associated Molecular Patterns (mtDAMPs) and Senescence-Associated Secretory Phenotype (SASP) nanNOT_YET_RECRUITING
Glycine and Magnesium+Thiamine for the Treatment of Primary Ciliary Dyskinesia nanRECRUITING
Multi-omics Study in Citrin Deficiency nanACTIVE_NOT_RECRUITING
Natural History Study - Mitochondrial Disease nanRECRUITING
Ataxia-telangiectasia: Treating Mitochondrial Dysfunction With Nicotinamide Riboside nanUNKNOWN
Lifestyle Intervention in Preparation for Pregnancy (LIPP) nanCOMPLETED
Nephroprotective Effects of Carnitine and (PDE5) Inhibitor Agent Against Contrast Media-induced Nephropathy (CMN) nanUNKNOWN
McArdle Disease Treatment by Ketogenic Diet nanCOMPLETED
Evaluation of Transcranial Photobiomodulation in Autism Spectrum Disorder nanCOMPLETED
Transcranial Photobiomodulation Therapy for the Treatment of Autistic Traits in Children and Adolescents With ADHD nanCOMPLETED
Mitoquines in COPD nanUNKNOWN
Tissue Sample Study for Mitochondrial Disorders nanENROLLING_BY_INVITATION
Early Mobilization and Intensive Rehabilitation in the Critically Ill nanUNKNOWN
Genetic Diagnosis in Inborn Errors of Metabolism nanENROLLING_BY_INVITATION
Clinical Study of Hydroxytyrosol (HT) in Mitochondrial Diseases nanCOMPLETED
Gastrointestinal Dysfunction in Children Affected With Mitochondrial Disorders nanCOMPLETED
Targeting Acute Myeloid Leukemia Immunosuppressive Microenvironment by combinedIDO1 Inhibition and PD-1 Blockade nanRECRUITING
Effect of Acute Fructose Load in Human nanCOMPLETED
TBI Multimodal Monitoring Study nanUNKNOWN
Pilot Study of Resveratrol in Older Adults With Impaired Glucose Tolerance nanCOMPLETED
Transgenerational Metabolic-Immune Biomarkers of Neurological and Neurodevelopmental Disorders nanRECRUITING
Abnormalities in the Effects of Insulin and Exercise on Glucose- and Lipid Metabolism in Obesity and Type 2 Diabetes nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a ME3 binder may also engage these)

ProteinNameSimilarity
Q8BMF3 — 1.000 Q8BMF3 →
P28227 — 0.995 P28227 →
P40927 — 0.993 P40927 →
P13697 — 0.990 P13697 →
ME1 NADP-dependent malic enzyme 0.989 landscape →
Q29558 — 0.987 Q29558 →
P06801 — 0.986 P06801 →
Q64HZ9 — 0.981 Q64HZ9 →
Q64HZ8 — 0.978 Q64HZ8 →
P00367 — 0.978 P00367 →
Q64I01 — 0.977 Q64I01 →
Q64I00 — 0.976 Q64I00 →
P10860 — 0.976 P10860 →
P49448 — 0.975 P49448 →
P26443 — 0.975 P26443 →
P42174 — 0.975 P42174 →
P00366 — 0.974 P00366 →
P12628 — 0.974 P12628 →
Q9YH58 — 0.973 Q9YH58 →
Q02053 — 0.972 Q02053 →
PC Pyruvate carboxylase, mitochondrial 0.972 landscape →
Q8CIG8 — 0.972 Q8CIG8 →
PRMT5 Protein arginine N-methyltransferase 5 0.972 landscape →
Q5U300 — 0.972 Q5U300 →
Q641Y5 — 0.972 Q641Y5 →
P31254 — 0.972 P31254 →
Q9XGZ0 — 0.971 Q9XGZ0 →
Q9LYG3 — 0.971 Q9LYG3 →
Q5R698 — 0.970 Q5R698 →
P34105 — 0.970 P34105 →