Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 16/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 7/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 7/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 7/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | RXRA | P19793 | 1/20 | 0.37 |
| ▸ | VNN1 | O95497 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7906674 | 0.81 | PDE4A (0.53) | PDE4AKCNH2 | |
| SCHEMBL7899112 | 0.79 | PDE4A (0.67) | PDE4AKCNH2 | |
| SCHEMBL7911732 | 0.78 | PDE4A (0.39) | PDE4AKCNH2 | |
| SCHEMBL7899038 | 0.77 | PDE4A (0.50) | PDE4AKCNH2 | |
| SCHEMBL7908333 | 0.76 | PDE4A (0.49) | PDE4AKCNH2 | |
| SCHEMBL7916558 | 0.76 | PDE4A (0.63) | PDE4AKCNH2 | |
| SCHEMBL7911687 | 0.76 | PDE4A (0.63) | PDE4AKCNH2 | |
| SCHEMBL7899076 | 0.76 | PDE4A (0.48) | PDE4AKCNH2 | |
| SCHEMBL7907874 | 0.74 | PDE4A (0.53) | PDE4APDE4BPDE4CPDE4DHDAC1 | |
| SCHEMBL7911699 | 0.69 | PDE4A (0.69) | PDE4AKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6200993-B1 | ASTHMA; ANTIINFLAMMATORY AGENTS | MERCK FROSST CANADA & CO. (CA) | 2001-03-13 | — | — | US | disclosed |