Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 6/20 | 0.53 |
| ▸ | VNN1 | O95497 | 8/20 | 0.53 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.44 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31365135 | 0.76 | VNN1 (0.58) | VNN1HDAC6HDAC3HDAC1HDAC2 | |
| SCHEMBL22031932 | 0.76 | VNN1 (0.58) | VNN1HDAC6HDAC3HDAC1HDAC2 | |
| SCHEMBL4160646 | 0.75 | PDE4A (0.61) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7908376 | 0.74 | PDE4A (0.44) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7905267 | 0.70 | PDE4A (1.00) | PDE4A | |
| SCHEMBL7991282 | 0.70 | LMNA (0.54) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL18286324 | 0.69 | VNN1 (1.00) | VNN1HDAC6HDAC3HDAC1HDAC2 | |
| SCHEMBL7994597 | 0.67 | LMNA (0.43) | PDE4AVNN1PDE4BPDE4CPDE4D | |
| SCHEMBL20185766 | 0.67 | VNN1 (1.00) | VNN1HDAC6HDAC3HDAC1HDAC2 | |
| SCHEMBL15100708 | 0.67 | MAPT (0.48) | PDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6200993-B1 | ASTHMA; ANTIINFLAMMATORY AGENTS | MERCK FROSST CANADA & CO. (CA) | 2001-03-13 | — | — | US | disclosed |