SCHEMBL7899274

CN(C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C1(C/C=C/C(=O)O)CCC1)[C@H](Cc1ccccc1)C(=O)N1CCC[C@H](C(C)(C)N)C1

nearest known ligand 0.45

Predicted protein targets (top 5)

	gene	UniProt	supporting neighbours	confidence
▸	GHSR	Q92847	3/20	0.38

▸	TACR1	P25103	7/20	0.36

▸	OPRD1	P41143	1/20	0.35

▸	PLAU	P00749	2/20	0.35

▸	F10	P00742	2/20	0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL866609	0.87	GHSR (0.44)	GHSRTACR1OPRD1PLAUF10
SCHEMBL1401068	0.83	GHSR (0.53)	GHSRTACR1OPRD1
SCHEMBL1401262	0.81	F10 (0.43)	GHSRTACR1PLAUF10
SCHEMBL3394198	0.76	TACR1 (0.38)	GHSRTACR1F10
SCHEMBL866610	0.75	GHSR (0.42)	GHSRTACR1OPRD1PLAUF10
SCHEMBL866611	0.75	GHSR (0.42)	GHSRTACR1OPRD1PLAUF10
SCHEMBL1401071	0.73	GHSR (0.52)	GHSRTACR1OPRD1
SCHEMBL1401070	0.73	GHSR (0.52)	GHSRTACR1OPRD1
SCHEMBL867608	0.73	GHSR (0.45)	GHSRTACR1OPRD1
SCHEMBL7896416	0.73	GHSR (0.45)	GHSRTACR1OPRD1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
EP-1100824-A1	COMPOUNDS WITH GROWTH HORMONE RELEASING PROPERTIES	NOVO NORDISK A/S (DK)	2001-05-23	—	—	EP	disclosed
WO-2000001726-A1	COMPOUNDS WITH GROWTH HORMONE RELEASING PROPERTIES	NOVO NORDISK A/S (DK)	2000-01-13	—	—	WO	disclosed