Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.60 |
| ▸ | RAB9A | P51151 | 6/20 | 0.60 |
| ▸ | NPC1 | O15118 | 5/20 | 0.60 |
| ▸ | MAPT | P10636 | 3/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | GAA | P10253 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | EGFR | P00533 | 1/20 | 0.49 |
| ▸ | MAOA | P21397 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10464759 | 0.88 | RAB9A (0.62) | SMN1; SMN2RAB9ANPC1MAPTKDM4E | |
| SCHEMBL21708013 | 0.86 | MAPT (0.67) | SMN1; SMN2RAB9ANPC1MAPTKDM4E | |
| SCHEMBL21708015 | 0.86 | MAPT (0.67) | SMN1; SMN2RAB9ANPC1MAPTKDM4E | |
| SCHEMBL789722 | 0.85 | MAPT (0.73) | SMN1; SMN2RAB9ANPC1MAPTKDM4E | |
| SCHEMBL4789312 | 0.82 | SMN1; SMN2 (0.69) | SMN1; SMN2RAB9ANPC1MAPTKDM4E | |
| SCHEMBL798484 | 0.82 | NPC1 (0.55) | SMN1; SMN2RAB9ANPC1MAPTKDM4E | |
| SCHEMBL3602966 | 0.81 | RAB9A (0.71) | SMN1; SMN2RAB9ANPC1MAPTKDM4E | |
| SCHEMBL23742650 | 0.80 | MAPT (0.53) | SMN1; SMN2RAB9ANPC1MAPTTDP1 | |
| SCHEMBL10464406 | 0.80 | MAPT (0.65) | SMN1; SMN2RAB9ANPC1MAPTKDM4E | |
| SCHEMBL31507493 | 0.79 | RAB9A (0.54) | SMN1; SMN2RAB9ANPC1MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012037349-A2 | COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2012-03-22 | — | — | WO | disclosed |
| WO-2012037351-A1 | COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2012-03-22 | — | — | WO | disclosed |