SCHEMBL7900548

SCHEMBL7900548

CNc1nc(SCc2csc(-c3ccc(Cl)cc3)n2)c(C#N)c(-c2ccc(CCCOC(=O)CCN)cc2)c1C#N

nearest known ligand 0.55

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
ADORA1 P30542 19/20 0.55
SLC6A3 Q01959 1/20 0.55
KDM4E B2RXH2 1/20 0.41
MEN1 O00255 1/20 0.41
ALDH1A1 P00352 1/20 0.41
RECQL P46063 1/20 0.41
KMT2A Q03164 1/20 0.41
HIF1A Q16665 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13261213 0.92 ADORA1 (0.64) ADORA1SLC6A3
Trifluoroacetic Acid SCHEMBL3724542 0.88 ADORA1 (0.59) ADORA1SLC6A3
SCHEMBL7901799 0.87 ADORA1 (0.55) ADORA1SLC6A3KDM4E
SCHEMBL7648982 0.85 ADORA1 (0.63) ADORA1SLC6A3
SCHEMBL13227898 0.85 ADORA1 (0.58) ADORA1SLC6A3
SCHEMBL13944629 0.84 ADORA1 (0.67) ADORA1SLC6A3
Hydrochloric Acid SCHEMBL3706093 0.84 ADORA1 (0.62) ADORA1SLC6A3
SCHEMBL7903266 0.84 ADORA1 (0.60) ADORA1SLC6A3
SCHEMBL7905915 0.82 ADORA1 (0.64) ADORA1SLC6A3
SCHEMBL7647506 0.82 ADORA1 (0.62) ADORA1SLC6A3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2010086101-A1 ALKYLAMINE-SUBSTITUTED DICYANOPYRIDINE AND AMINO ACID ESTER PRODRUGS THEREOF BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) 2010-08-05 WO disclosed