SCHEMBL7900688

SCHEMBL7900688

NCCCCCCCCCCCC#Cc1ccccc1

nearest known ligand 0.70

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 3/20 0.57
CYP3A4 P08684 3/20 0.57
CYP2C9 P11712 3/20 0.57
CYP2C19 P33261 3/20 0.57
THPO P40225 1/20 0.57
BLM P54132 1/20 0.55
PMP22 Q01453 1/20 0.55
HTR2A P28223 1/20 0.44
HRH3 Q9Y5N1 1/20 0.43
APP P05067 1/20 0.42
MAOA P21397 1/20 0.42
ALDH1A1 P00352 2/20 0.40
MAPT P10636 2/20 0.40
TSHR P16473 1/20 0.40
ADORA3 P0DMS8 1/20 0.40
FFAR1 O14842 1/20 0.40
FFAR4 Q5NUL3 1/20 0.40
KDM4E B2RXH2 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7893024 0.98 CYP1A2 (0.59) CYP1A2CYP3A4CYP2C9CYP2C19THPO
SCHEMBL1444744 0.83 CYP1A2 (0.67) CYP1A2CYP3A4CYP2C9CYP2C19THPO
SCHEMBL17911731 0.83 CYP1A2 (0.58) CYP1A2CYP3A4CYP2C9CYP2C19THPO
SCHEMBL19523535 0.82 MAPT (0.63) CYP1A2CYP3A4CYP2C9CYP2C19THPO
Hydrochloric Acid SCHEMBL9018599 0.81 BLM (0.68) CYP1A2CYP3A4CYP2C9CYP2C19THPO
SCHEMBL23014997 0.80 CYP1A2 (0.56) CYP1A2CYP3A4CYP2C9CYP2C19THPO
SCHEMBL9015870 0.80 FFAR1 (0.58) CYP1A2CYP3A4CYP2C9CYP2C19THPO
SCHEMBL4073903 0.80 FFAR1 (0.58) CYP1A2CYP3A4CYP2C9CYP2C19THPO
SCHEMBL4071200 0.80 FFAR1 (0.58) CYP1A2CYP3A4CYP2C9CYP2C19THPO
SCHEMBL4948108 0.80 CYP1A2 (0.56) CYP1A2CYP3A4CYP2C9CYP2C19THPO

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6197797-B1 ANTICANCER AGENTS; SKIN DISORDERS Leo Pharmaceutical Products Ltd. A/S (Løvens Kemiske Fabrik Produktionsaktieselskab) (DK) 2001-03-06 US disclosed
EP-0984939-A1 CYANOGUANIDINES AS CELL PROLIFERATION INHIBITORS LEO PHARMACEUTICAL PRODUCTS LTD. A/S (LOVENS KEMISKE FABRIK PRODUKTIONSAKTIESELSKAB) (DK) 2000-03-15 EP disclosed
WO-1998054145-A1 CYANOGUANIDINES AS CELL PROLIFERATION INHIBITORS Leo Pharmaceutical Products Ltd. A/S (Løvens Kemiske Fabrik Produktionsaktieselskab) (DK) 1998-12-03 WO disclosed