Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.47 |
| ▸ | THPO | P40225 | 1/20 | 0.47 |
| ▸ | BLM | P54132 | 1/20 | 0.45 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | APP | P05067 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.40 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | MMP12 | P39900 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9428903 | 0.98 | KDM4E (0.49) | KDM4ECYP3A4CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL10455227 | 0.85 | CYP1A2 (0.52) | KDM4ECYP3A4CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL17911731 | 0.83 | CYP1A2 (0.58) | KDM4ECYP3A4CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL2707756 | 0.80 | CYP1A2 (0.47) | CYP3A4CYP1A2CYP2C9CYP2C19THPO | |
| SCHEMBL7900688 | 0.80 | CYP1A2 (0.57) | KDM4ECYP3A4CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL23014997 | 0.80 | CYP1A2 (0.56) | KDM4ECYP3A4CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL4948108 | 0.80 | CYP1A2 (0.56) | KDM4ECYP3A4CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL8522596 | 0.80 | CYP1A2 (0.47) | CYP3A4CYP1A2CYP2C9CYP2C19THPO | |
| SCHEMBL8590492 | 0.80 | CYP1A2 (0.47) | CYP3A4CYP1A2CYP2C9CYP2C19THPO | |
| SCHEMBL7139040 | 0.80 | FFAR1 (0.58) | CYP3A4CYP1A2CYP2C9CYP2C19THPO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9994602-B2 | Spiroannulated nucleosides and process for the preparation thereof | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2018-06-12 | — | — | US | disclosed |
| US-20160185811-A1 | Spiroannulated nucleosides and process for the preparation thereof | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2016-06-30 | — | — | US | disclosed |
| US-9346847-B2 | Spiroannulated nucleosides and process for the preparation thereof | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2016-05-24 | — | — | US | disclosed |
| EP-2658862-A1 | SPIROANNULATED NUCLEOSIDES AND PROCESS FOR THE PREPARATION THEREOF | Council of Scientific & Industrial Research (IN) | 2013-11-06 | — | — | EP | disclosed |
| US-20130289266-A1 | Spiroannulated Nucleosides and Process for the Preparation Thereof | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2013-10-31 | — | — | US | disclosed |
| WO-2012090155-A1 | SPIROANNULATED NUCLEOSIDES AND PROCESS FOR THE PREPARATION THEREOF | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2012-07-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160185811-A1 | Spiroannulated nucleosides and process for the preparation thereof | DCK, DUT, GNE | KDM4E 4045/4885CYP3A4 1417/4885CYP1A2 1665/4885 |
| US-20130289266-A1 | Spiroannulated Nucleosides and Process for the Preparation Thereof | DCK, DHPS, DUT | KDM4E 3742/4885CYP3A4 1084/4885CYP1A2 1186/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.