Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.53 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.53 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 4/20 | 0.52 |
| ▸ | JMJD6 | Q6NYC1 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.50 |
| ▸ | RAB9A | P51151 | 5/20 | 0.50 |
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | NPC1 | O15118 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.43 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3595480 | 0.83 | LMNA (0.51) | TDP1KMT2ASLC6A2SLC6A3LMNA | |
| SCHEMBL4255360 | 0.82 | CA12 (0.51) | TDP1LMNAJMJD6ALDH1A1RAB9A | |
| SCHEMBL26781901 | 0.81 | MAPT (0.50) | TDP1KMT2ASLC6A2SLC6A3LMNA | |
| SCHEMBL7423685 | 0.80 | JMJD6 (0.45) | TDP1KMT2ASLC6A2SLC6A3LMNA | |
| SCHEMBL6002245 | 0.80 | KMT2A (0.70) | TDP1KMT2ASLC6A2SLC6A3LMNA | |
| SCHEMBL2706461 | 0.77 | KMT2A (0.66) | TDP1KMT2ASLC6A2SLC6A3LMNA | |
| SCHEMBL11862997 | 0.77 | KMT2A (0.66) | TDP1KMT2ASLC6A2SLC6A3LMNA | |
| SCHEMBL30623233 | 0.77 | KDM4E (0.56) | TDP1LMNAALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL232145 | 0.77 | KDM4E (0.56) | TDP1LMNAALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL5066704 | 0.77 | TDP1 (0.50) | TDP1KMT2ASLC6A2SLC6A3LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6211223-B1 | BENZODIOXOL-5-YL-2-METHOXY-4-METHYLPHENYLSULFONYLAMINO-2-OXO ETHYL-1-METHYL-1HINDOLE-6-CARBOXYLIC ACID | PFIZER INC. | 2001-04-03 | — | — | US | disclosed |
| WO-1999020623-A1 | INDOLE DERIVATIVE USEFUL AS ENDOTHELIN RECEPTOR ANTAGONIST | PFIZER LIMITED (GB) | 1999-04-29 | — | — | WO | disclosed |