Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 18/20 | 1.00 |
| ▸ | FAP | Q12884 | 17/20 | 1.00 |
| ▸ | DPP7 | Q9UHL4 | 9/20 | 1.00 |
| ▸ | DPP8 | Q6V1X1 | 3/20 | 0.71 |
| ▸ | DPP9 | Q86TI2 | 3/20 | 0.71 |
| ▸ | PREP | P48147 | 7/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8285585 | 0.98 | DPP4 (1.00) | DPP4FAPDPP7DPP8DPP9 | |
| SCHEMBL8285586 | 0.97 | DPP4 (1.00) | DPP4FAPDPP7DPP8DPP9 | |
| SCHEMBL3204887 | 0.95 | DPP4 (1.00) | DPP4FAPDPP7DPP8DPP9 | |
| SCHEMBL13347170 | 0.90 | DPP4 (0.89) | DPP4FAPDPP7DPP8DPP9 | |
| SCHEMBL8288236 | 0.90 | DPP4 (0.89) | DPP4FAPDPP7DPP8DPP9 | |
| SCHEMBL7896597 | 0.88 | FAP (0.85) | DPP4FAPDPP7DPP8DPP9 | |
| SCHEMBL8286771 | 0.88 | DPP4 (0.86) | DPP4FAPDPP7DPP8DPP9 | |
| SCHEMBL8288243 | 0.88 | DPP4 (0.86) | DPP4FAPDPP7DPP8DPP9 | |
| SCHEMBL8286766 | 0.87 | FAP (0.82) | DPP4FAPDPP7DPP8DPP9 | |
| SCHEMBL8287954 | 0.86 | DPP4 (0.77) | DPP4FAPDPP7DPP8DPP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1997533-B1 | Heterocyclic boronic acid compounds, dipeptidyl peptidase IV inhibitors | PHENOMIX CORP (US) | 2014-09-24 | — | — | EP | disclosed |
| EP-1689757-B1 | HETEROCYCLIC BORONIC ACID COMPOUNDS | PHENOMIX CORP (US) | 2014-08-27 | — | — | EP | disclosed |
| US-8415295-B2 | Heterocyclic boronic acid compounds | PHENOMIX CORPORATION (US) | 2013-04-09 | — | — | US | disclosed |
| US-8415295-B2 | Heterocyclic boronic acid compounds | PHENOMIX CORPORATION (US) | 2013-04-09 | — | — | US | disclosed |
| US-7906658-B2 | Antidiabetic agents | PHENOMIX CORPORATION (US) | 2011-03-15 | — | — | US | disclosed |
| US-7906658-B2 | Antidiabetic agents | PHENOMIX CORPORATION (US) | 2011-03-15 | — | — | US | disclosed |
| US-7884217-B2 | Antidiabetic agents | PHENOMIX CORPORATION (US) | 2011-02-08 | — | — | US | disclosed |
| US-7884217-B2 | Antidiabetic agents | PHENOMIX CORPORATION (US) | 2011-02-08 | — | — | US | disclosed |
| US-7825139-B2 | Compounds and methods for selective inhibition of dipeptidyl peptidase-IV | Forest Laboratories Holdings Limited (BM) | 2010-11-02 | — | — | US | disclosed |
| US-7825139-B2 | Compounds and methods for selective inhibition of dipeptidyl peptidase-IV | Forest Laboratories Holdings Limited (BM) | 2010-11-02 | — | — | US | disclosed |
| US-20070185061-A1 | (2R)-1-{2-[(3R)-pyrrolidin-3-ylamino]-acetyl}-pyrrolidine-2-boronic acid; Dipeptidyl peptidase IV (DPP-IV) inhibitors; diabetes, hyperglycemia, Syndrome X, hyperinsulinemia, obesity, atherosclerosis | PHENOMIX CORPORATION | 2007-08-09 | — | — | US | disclosed |
| US-20070185061-A1 | (2R)-1-{2-[(3R)-pyrrolidin-3-ylamino]-acetyl}-pyrrolidine-2-boronic acid; Dipeptidyl peptidase IV (DPP-IV) inhibitors; diabetes, hyperglycemia, Syndrome X, hyperinsulinemia, obesity, atherosclerosis | PHENOMIX CORPORATION | 2007-08-09 | — | — | US | disclosed |
| US-20070060547-A1 | (2R)-1-{2-[(3R)-pyrrolidin-3-ylamino]-acetyl}-pyrrolidine-2-boronic acid; Dipeptidyl peptidase IV (DPP-IV) inhibitors; diabetes, hyperglycemia, Syndrome X, hyperinsulinemia, obesity, atherosclerosis | PHENOMIX CORPORATION | 2007-03-15 | — | — | US | disclosed |
| US-20070060547-A1 | (2R)-1-{2-[(3R)-pyrrolidin-3-ylamino]-acetyl}-pyrrolidine-2-boronic acid; Dipeptidyl peptidase IV (DPP-IV) inhibitors; diabetes, hyperglycemia, Syndrome X, hyperinsulinemia, obesity, atherosclerosis | PHENOMIX CORPORATION | 2007-03-15 | — | — | US | disclosed |
| EP-1743676-A1 | Heterocyclic boronic acid derivatives, dipeptidyl peptidase IV inhibitors | Phenomix Corporation (US) | 2007-01-17 | — | — | EP | disclosed |
| US-20060276410-A1 | COMPOUNDS AND METHODS FOR SELECTIVE INHIBITION OF DIPEPTIDYL PEPTIDASE-IV | Forest Laboratories Holding Limited (BM) | 2006-12-07 | — | — | US | disclosed |
| US-20060276410-A1 | COMPOUNDS AND METHODS FOR SELECTIVE INHIBITION OF DIPEPTIDYL PEPTIDASE-IV | Forest Laboratories Holding Limited (BM) | 2006-12-07 | — | — | US | disclosed |
| US-20060264400-A1 | PYRROLIDINE COMPOUNDS AND METHODS FOR SELECTIVE INHIBITION OF DIPEPTIDYL PEPTIDASE-IV | SINO-MED INTERNATIONAL ALLIANCE, INC. | 2006-11-23 | — | — | US | disclosed |
| US-20060264400-A1 | PYRROLIDINE COMPOUNDS AND METHODS FOR SELECTIVE INHIBITION OF DIPEPTIDYL PEPTIDASE-IV | SINO-MED INTERNATIONAL ALLIANCE, INC. | 2006-11-23 | — | — | US | disclosed |
| WO-2005047297-A1 | HETEROCYCLIC BORONIC ACID COMPOUNDS | PHENOMIX CORPORATION (US) | 2005-05-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060276410-A1 | COMPOUNDS AND METHODS FOR SELECTIVE INHIBITION OF DIPEPTIDYL PEPTIDASE-IV | DPP4, DPP3, DPP7 | DPP4 1/4885FAP 16/4885DPP7 3/4885 |
| US-20070060547-A1 | (2R)-1-{2-[(3R)-pyrrolidin-3-ylamino]-acetyl}-pyrrolidine-2-boronic acid; Dipeptidyl peptidase IV (DPP-IV) inhibitors; diabetes, hyperglycemia, Syndrome X, hyperinsulinemia, obesity, atherosclerosis | DPP4, DPP7, DPP3 | DPP4 1/4885FAP 269/4885DPP7 2/4885 |
| US-20060264400-A1 | PYRROLIDINE COMPOUNDS AND METHODS FOR SELECTIVE INHIBITION OF DIPEPTIDYL PEPTIDASE-IV | DPP4, DPP7, DPP3 | DPP4 1/4885FAP 22/4885DPP7 2/4885 |
| US-20070185061-A1 | (2R)-1-{2-[(3R)-pyrrolidin-3-ylamino]-acetyl}-pyrrolidine-2-boronic acid; Dipeptidyl peptidase IV (DPP-IV) inhibitors; diabetes, hyperglycemia, Syndrome X, hyperinsulinemia, obesity, atherosclerosis | DPP4, DPP7, DPP3 | DPP4 1/4885FAP 209/4885DPP7 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.