Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 20/20 | 0.57 |
| ▸ | PDE6C | P51160 | 1/20 | 0.49 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7904959 | 0.84 | PDE5A (0.69) | PDE5APDE6CPDE11A | |
| SCHEMBL7904851 | 0.82 | PDE5A (0.58) | PDE5APDE6CPDE11A | |
| SCHEMBL7904974 | 0.81 | PDE5A (0.56) | PDE5APDE6CPDE11A | |
| SCHEMBL7904848 | 0.81 | PDE5A (0.51) | PDE5APDE6CPDE11A | |
| SCHEMBL7902715 | 0.78 | PDE5A (0.59) | PDE5APDE6CPDE11A | |
| SCHEMBL7899630 | 0.77 | PDE5A (0.58) | PDE5APDE6C | |
| SCHEMBL7901187 | 0.76 | PDE5A (0.55) | PDE5APDE6CPDE11A | |
| SCHEMBL7902714 | 0.76 | PDE5A (0.55) | PDE5APDE6CPDE11A | |
| SCHEMBL8471415 | 0.75 | PDE5A (0.62) | PDE5APDE6CPDE11A | |
| SCHEMBL3840535 | 0.74 | PDE5A (0.68) | PDE5APDE6CPDE11A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6187779-B1 | ADMINISTERING ANTITUMOR AGENTS TO TREAT COLON CANCER | CELL PATHWAYS, INC. | 2001-02-13 | — | — | US | disclosed |
| US-5721238-A | ANTIINFLAMMATORY AGENTS, CARDIOVASCULAR DISORDERS | BAYER AKTIENGESELLSCHAFT (DE) | 1998-02-24 | — | — | US | disclosed |
| EP-0722937-A1 | 2,8-Disubstituted quinazolinone | BAYER AG (DE) | 1996-07-24 | — | — | EP | disclosed |