Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | POLB | P06746 | 3/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | UBE2N | P61088 | 4/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL518426 | 0.90 | KMT2A (0.59) | KMT2AALDH1A1POLBCYP2C9L3MBTL1 | |
| SCHEMBL518427 | 0.90 | KMT2A (0.59) | KMT2AALDH1A1POLBCYP2C9L3MBTL1 | |
| SCHEMBL518576 | 0.89 | KMT2A (0.61) | KMT2AALDH1A1POLBCYP2C9L3MBTL1 | |
| SCHEMBL518577 | 0.89 | KMT2A (0.61) | KMT2AALDH1A1POLBCYP2C9L3MBTL1 | |
| SCHEMBL518765 | 0.89 | MAPT (0.58) | KMT2AALDH1A1POLBCYP2C9L3MBTL1 | |
| SCHEMBL13260236 | 0.89 | ALDH1A1 (0.45) | KMT2AALDH1A1POLBCYP2C9L3MBTL1 | |
| SCHEMBL518764 | 0.89 | MAPT (0.58) | KMT2AALDH1A1POLBCYP2C9L3MBTL1 | |
| SCHEMBL8370640 | 0.89 | KMT2A (0.45) | KMT2AALDH1A1POLBCYP2C9L3MBTL1 | |
| SCHEMBL519441 | 0.88 | CYP2C9 (0.61) | KMT2AALDH1A1POLBCYP2C9L3MBTL1 | |
| SCHEMBL519440 | 0.88 | CYP2C9 (0.61) | KMT2AALDH1A1POLBCYP2C9L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010063610-A1 | PYRIDAZINONE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2010-06-10 | — | — | WO | disclosed |