Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 10/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | F2RL3 | Q96RI0 | 1/20 | 0.39 |
| ▸ | FSCN1 | Q16658 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | PDE5A | O76074 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | PKLR | P30613 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3708584 | 0.91 | F2RL3 (0.41) | CHRM1ALDH1A1KDM4EF2RL3FSCN1 | |
| SCHEMBL3713264 | 0.79 | GABRA1 (0.37) | CHRM1F2RL3FSCN1POLBPDE5A | |
| SCHEMBL7913305 | 0.79 | GABRA1 (0.41) | CHRM1F2RL3FSCN1POLBPDE5A | |
| SCHEMBL3779687 | 0.76 | GRM2 (0.39) | CHRM1ALDH1A1F2RL3FSCN1POLB | |
| SCHEMBL14875518 | 0.72 | GRM2 (0.39) | CHRM1ALDH1A1F2RL3FSCN1POLB | |
| SCHEMBL7906411 | 0.70 | FGFR1 (0.47) | CHRM1F2RL3 | |
| SCHEMBL4478716 | 0.70 | F2RL3 (0.60) | ALDH1A1KDM4EF2RL3PDE5AMAPT | |
| SCHEMBL7907818 | 0.69 | PDE5A (0.34) | CHRM1ALDH1A1KDM4EF2RL3FSCN1 | |
| SCHEMBL3805510 | 0.69 | GRN (0.43) | CHRM1FSCN1PDE5AKMT2A | |
| SCHEMBL7909375 | 0.68 | CYP11B1 (0.41) | CHRM1ALDH1A1KDM4EPDE5AHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010096338-A1 | PYRAZOLO [4,3-c] CINNOLIN-3-ONE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | MERCK SHARP & DOHME CORP. (US) | 2010-08-26 | — | — | WO | disclosed |