Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARG | P13631 | 12/20 | 0.69 |
| ▸ | RARB | P10826 | 11/20 | 0.69 |
| ▸ | RARA | P10276 | 10/20 | 0.69 |
| ▸ | MEN1 | O00255 | 3/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.69 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.69 |
| ▸ | TP53 | P04637 | 1/20 | 0.69 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.69 |
| ▸ | MAPT | P10636 | 1/20 | 0.69 |
| ▸ | HPGD | P15428 | 1/20 | 0.69 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.69 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.69 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.69 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.69 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.69 |
| ▸ | THRB | P10828 | 1/20 | 0.61 |
| ▸ | RECQL | P46063 | 1/20 | 0.61 |
| ▸ | NR2E1 | Q9Y466 | 1/20 | 0.61 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9300831 | 0.85 | RARB (0.69) | RARGRARBRARAMEN1KMT2A | |
| O-Demethylated Adapalene SCHEMBL174205 | 0.81 | RARG (1.00) | RARGRARBRARAMEN1KMT2A | |
| O-Demethylated Adapalene SCHEMBL29727107 | 0.81 | RARG (1.00) | RARGRARBRARAMEN1KMT2A | |
| O-Demethylated Adapalene SCHEMBL29357288 | 0.81 | RARG (1.00) | RARGRARBRARAMEN1KMT2A | |
| O-Demethylated Adapalene SCHEMBL29357074 | 0.81 | RARG (1.00) | RARGRARBRARAMEN1KMT2A | |
| SCHEMBL2912783 | 0.81 | RARG (0.71) | RARGRARBRARAMEN1KMT2A | |
| SCHEMBL9331667 | 0.79 | RARB (0.56) | RARGRARBRARAMEN1KMT2A | |
| SCHEMBL8766318 | 0.79 | RARG (0.77) | RARGRARBRARAMEN1KMT2A | |
| Adapalene SCHEMBL4915067 | 0.79 | RARB (0.92) | RARGRARBRARAMEN1KMT2A | |
| SCHEMBL12257861 | 0.79 | MEN1 (0.74) | RARGRARBRARAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110114338-B | Retinoid derivatives having antitumor activity | 比奥吉公司 | 2022-10-21 | — | — | CN | disclosed |
| US-20120183600-A1 | NOVEL COMPOSITION FOR TREATING METABOLIC SYNDROME AND OTHER CONDITIONS | CHEN CHIEN-HUNG (US) | 2012-07-19 | — | — | US | disclosed |
| US-6211239-B1 | Method for treating or preventing breast cancer or leukemia using 6-[3-[1-adamantyl]-4-hydroxyphenyl]-2-naphthalene carboxylic acid (AHPN) | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) | 2001-04-03 | — | — | US | disclosed |
| EP-0850067-A4 | METHOD FOR TREATING CANCERS USING 6- 3- 1-ADAMANTYL]-4-HYDROXYPHENYL] | CIRD GALDERMA (FR) | 1999-12-15 | — | — | EP | disclosed |
| EP-0850067-A1 | METHOD FOR TREATING CANCERS USING 6- 3- 1-ADAMANTYL]-4-HYDROXYPHENYL] | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (C.I.R.D. GALDERMA) (FR) | 1998-07-01 | — | — | EP | disclosed |
| WO-1997003682-A1 | METHOD FOR TREATING CANCERS USING 6-[3-[1-ADAMANTYL]-4-HYDROXYPHENYL] | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES C.I.R.D. GALDERMA (FR) | 1997-02-06 | — | — | WO | disclosed |