Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 9/20 | 1.00 |
| ▸ | MTOR | P42345 | 4/20 | 1.00 |
| ▸ | PIK3R1 | P27986 | 7/20 | 0.68 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.68 |
| ▸ | JAK2 | O60674 | 1/20 | 0.68 |
| ▸ | JAK1 | P23458 | 1/20 | 0.68 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.68 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.68 |
| ▸ | JAK3 | P52333 | 1/20 | 0.68 |
| ▸ | HDAC1 | Q13547 | 14/20 | 0.58 |
| ▸ | HDAC3 | O15379 | 11/20 | 0.58 |
| ▸ | HDAC4 | P56524 | 11/20 | 0.58 |
| ▸ | HDAC7 | Q8WUI4 | 11/20 | 0.58 |
| ▸ | HDAC2 | Q92769 | 11/20 | 0.58 |
| ▸ | HDAC10 | Q969S8 | 11/20 | 0.58 |
| ▸ | HDAC11 | Q96DB2 | 11/20 | 0.58 |
| ▸ | HDAC8 | Q9BY41 | 11/20 | 0.58 |
| ▸ | HDAC6 | Q9UBN7 | 11/20 | 0.58 |
| ▸ | HDAC9 | Q9UKV0 | 11/20 | 0.58 |
| ▸ | HDAC5 | Q9UQL6 | 11/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8066948 | 0.91 | PIK3CA (0.84) | PIK3CAMTORPIK3R1PIK3CDJAK2 | |
| SCHEMBL8055477 | 0.89 | PIK3CA (0.80) | PIK3CAMTORPIK3R1PIK3CDJAK2 | |
| SCHEMBL3655039 | 0.89 | PIK3CA (0.80) | PIK3CAMTORPIK3R1PIK3CDJAK2 | |
| SCHEMBL8079833 | 0.89 | PIK3CA (0.80) | PIK3CAMTORPIK3R1PIK3CDJAK2 | |
| SCHEMBL8053693 | 0.88 | PIK3CA (0.79) | PIK3CAMTORPIK3R1PIK3CDJAK2 | |
| SCHEMBL8062697 | 0.88 | PIK3CA (0.78) | PIK3CAMTORPIK3R1PIK3CDJAK2 | |
| SCHEMBL1569009 | 0.87 | PIK3CA (0.77) | PIK3CAMTORPIK3R1PIK3CDJAK2 | |
| SCHEMBL8063024 | 0.87 | PIK3CA (0.77) | PIK3CAMTORPIK3R1PIK3CDJAK2 | |
| SCHEMBL11986004 | 0.87 | PIK3CA (0.76) | PIK3CAMTORPIK3R1PIK3CDJAK2 | |
| SCHEMBL8053186 | 0.87 | PIK3CA (0.76) | PIK3CAMTORPIK3R1PIK3CDJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250011425-A1 | COMPOSITIONS AND METHODS FOR IMPROVED T CELLS | UNIV TEMPLE (US) | 2025-01-09 | — | — | US | claimed |
| US-12024715-B2 | Compositions and methods for improved T cells | TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2024-07-02 | — | — | US | claimed |
| US-20200270573-A1 | COMPOSITIONS AND METHODS FOR IMPROVED T CELLS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2020-08-27 | — | — | US | claimed |
| US-20250011425-A1 | COMPOSITIONS AND METHODS FOR IMPROVED T CELLS | UNIV TEMPLE (US) | 2025-01-09 | — | — | US | disclosed |
| US-12024715-B2 | Compositions and methods for improved T cells | TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2024-07-02 | — | — | US | disclosed |
| US-20170121332-A1 | PYRIMIDINE SUBSTITUTED PURINE COMPOUNDS AS KINASE (S) INHIBITORS | CHEN DIZHONG (SG) | 2017-05-04 | — | — | US | disclosed |
| US-20170121332-A1 | PYRIMIDINE SUBSTITUTED PURINE COMPOUNDS AS KINASE (S) INHIBITORS | CHEN DIZHONG (SG) | 2017-05-04 | — | — | US | disclosed |
| US-20170121332-A1 | PYRIMIDINE SUBSTITUTED PURINE COMPOUNDS AS KINASE (S) INHIBITORS | CHEN DIZHONG (SG) | 2017-05-04 | — | — | US | disclosed |
| US-20160207927-A1 | PYRIMIDINE SUBSTITUTED PURINE COMPOUNDS AS KINASE (S) INHIBITORS | VERASTEM INC (US) | 2016-07-21 | — | — | US | disclosed |
| US-20160207927-A1 | PYRIMIDINE SUBSTITUTED PURINE COMPOUNDS AS KINASE (S) INHIBITORS | VERASTEM INC (US) | 2016-07-21 | — | — | US | disclosed |
| US-20160207927-A1 | PYRIMIDINE SUBSTITUTED PURINE COMPOUNDS AS KINASE (S) INHIBITORS | VERASTEM INC (US) | 2016-07-21 | — | — | US | disclosed |
| US-8754080-B2 | Pyrimidine substituted purine compounds as kinase (S) inhibitors | VERASTEM, INC. (US) | 2014-06-17 | — | — | US | disclosed |
| US-8754080-B2 | Pyrimidine substituted purine compounds as kinase (S) inhibitors | VERASTEM, INC. (US) | 2014-06-17 | — | — | US | disclosed |
| EP-2414362-B1 | PYRIMIDINE SUBSTITUTED PURINE COMPOUNDS AS KINASE (S) INHIBITORS | VERASTEM INC (US) | 2014-06-11 | — | — | EP | disclosed |
| EP-2414362-B1 | PYRIMIDINE SUBSTITUTED PURINE COMPOUNDS AS KINASE (S) INHIBITORS | VERASTEM INC (US) | 2014-06-11 | — | — | EP | disclosed |
| US-20120142683-A1 | PYRIMIDINE SUBSTITUTED PURINE COMPOUNDS AS KINASE (S) INHIBITORS | S*BIO PTE LTD. (SG) | 2012-06-07 | — | — | US | disclosed |
| US-20120142683-A1 | PYRIMIDINE SUBSTITUTED PURINE COMPOUNDS AS KINASE (S) INHIBITORS | S*BIO PTE LTD. (SG) | 2012-06-07 | — | — | US | disclosed |
| US-20120142683-A1 | PYRIMIDINE SUBSTITUTED PURINE COMPOUNDS AS KINASE (S) INHIBITORS | S*BIO PTE LTD. (SG) | 2012-06-07 | — | — | US | disclosed |
| WO-2010114494-A1 | 8-SUBSTITUTED-2-MORPHOLINO PURINES FOR USE AS PI3K AND/OR MTOR INHIBITORS IN THE TREATMENT OF PROLIFERATIVE DISORDERS | S*BIO PTE LTD (SG) | 2010-10-07 | — | — | WO | disclosed |
| WO-2010114484-A1 | PYRIMIDINE SUBSTITUTED PURINE COMPOUNDS AS KINASE (S) INHIBITORS | S*BIO PTE LTD (SG) | 2010-10-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160207927-A1 | PYRIMIDINE SUBSTITUTED PURINE COMPOUNDS AS KINASE (S) INHIBITORS | DCK, CMPK1, PNP | PIK3CA 193/4885MTOR 251/4885PIK3R1 909/4885 |
| US-20170121332-A1 | PYRIMIDINE SUBSTITUTED PURINE COMPOUNDS AS KINASE (S) INHIBITORS | DCK, CMPK1, PNP | PIK3CA 193/4885MTOR 251/4885PIK3R1 909/4885 |
| US-20120142683-A1 | PYRIMIDINE SUBSTITUTED PURINE COMPOUNDS AS KINASE (S) INHIBITORS | DCK, CMPK1, PNP | PIK3CA 159/4885MTOR 249/4885PIK3R1 824/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.