Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 9/20 | 0.48 |
| ▸ | TNF | P01375 | 1/20 | 0.47 |
| ▸ | IGF1R | P08069 | 1/20 | 0.44 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.43 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.42 |
| ▸ | HTR3A | P46098 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.41 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | ALPL | P05186 | 1/20 | 0.40 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.40 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2461362 | 0.87 | FAAH (0.48) | FAAHTNFIGF1RGRM4TRPV1 | |
| SCHEMBL2457305 | 0.86 | FAAH (0.48) | FAAHTNFIGF1RGRM4TRPV1 | |
| SCHEMBL2455656 | 0.86 | FAAH (0.46) | FAAHTNFIGF1RGRM4TRPV1 | |
| SCHEMBL12220835 | 0.85 | FAAH (0.51) | FAAHTNFIGF1RGRM4MAPK1 | |
| SCHEMBL2460744 | 0.85 | FAAH (0.46) | FAAHTNFIGF1RGRM4TRPV1 | |
| SCHEMBL2461380 | 0.85 | FAAH (0.47) | FAAHTNFIGF1RGRM4TRPV1 | |
| SCHEMBL2536956 | 0.84 | FAAH (0.43) | FAAHTNFIGF1RGRM4TRPV1 | |
| SCHEMBL2457062 | 0.84 | FAAH (0.46) | FAAHTNFIGF1RGRM4TRPV1 | |
| SCHEMBL2462344 | 0.84 | FAAH (0.46) | FAAHTNFIGF1RGRM4TRPV1 | |
| SCHEMBL2457045 | 0.84 | FAAH (0.46) | FAAHTNFIGF1RTRPV1EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010059610-A1 | 6, 7 -DIHYDRO- 5H- PYRROLO [3, 4-D] PYRIMIDIN-4-YL] -QUINOLIN-3 -YLAMINE COMPOUNDS USEFUL AS FAAH MODULATORS AND USES THEREOF | RENOVIS, INC. (US) | 2010-05-27 | — | — | WO | disclosed |