Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | PDE4A | P27815 | 2/20 | 0.46 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.46 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.46 |
| ▸ | PDE5A | O76074 | 3/20 | 0.44 |
| ▸ | PDE2A | O00408 | 1/20 | 0.44 |
| ▸ | PDE1A | P54750 | 1/20 | 0.44 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.44 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7913140 | 0.97 | PDE5A (0.46) | KDM4ERXFP1ALDH1A1PDE4APDE4B | |
| SCHEMBL7918152 | 0.89 | PDE4A (0.57) | KDM4ERXFP1ALDH1A1PDE4APDE4B | |
| SCHEMBL7911667 | 0.88 | PDE4A (0.57) | KDM4ERXFP1ALDH1A1PDE4APDE4B | |
| SCHEMBL6597081 | 0.86 | PDE4A (0.57) | KDM4EALDH1A1PDE4APDE4BPDE4C | |
| SCHEMBL7914604 | 0.85 | PDE4A (0.57) | KDM4ERXFP1ALDH1A1PDE4APDE4B | |
| Hydrochloric Acid SCHEMBL6606090 | 0.85 | PDE5A (0.48) | KDM4ERXFP1ALDH1A1PDE4APDE4B | |
| SCHEMBL6592174 | 0.83 | PDE5A (0.58) | ALDH1A1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL12806899 | 0.78 | PDE5A (0.51) | KDM4ERXFP1ALDH1A1PDE4APDE4B | |
| SCHEMBL389143 | 0.77 | GPR119 (0.59) | KDM4ERXFP1ALDH1A1PDE4APDE4B | |
| SCHEMBL7904575 | 0.76 | PDE4A (0.72) | KDM4EALDH1A1PDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6218392-B1 | FOR THERAPY AND PROPHYLAXIS OF ISCHEMIC HEART DISEASES SUCH AS ANGINA PECTORIS, MYOCARDIAL INFARCT AND CHRONIC AND ACUTE CARDIAC FAILURE, PULMONARY HYPERTENSION, ARTERIOSCLEROSIS AND BRONCHIAL ASTHMA | EISAI CO., LTD. (JP) | 2001-04-17 | — | — | US | disclosed |
| EP-0722936-A1 | FUSED PYRIDAZINE COMPOUND | Eisai Co., Ltd. (JP) | 1996-07-24 | — | — | EP | disclosed |