Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5901243 | 0.98 | KMT2A (0.45) | KMT2AALDH1A1CYP2D6POLBMAPK1 | |
| SCHEMBL8442784 | 0.82 | KMT2A (0.51) | KMT2AALDH1A1CYP2D6POLBMAPK1 | |
| SCHEMBL489578 | 0.80 | CA1 (0.46) | KMT2AALDH1A1CYP2D6POLBMAPK1 | |
| SCHEMBL684394 | 0.80 | POLB (0.44) | KMT2AALDH1A1CYP2D6POLBMAPK1 | |
| SCHEMBL13212100 | 0.78 | POLB (0.43) | KMT2AALDH1A1CYP2D6POLBMAPK1 | |
| SCHEMBL2261416 | 0.78 | POLB (0.42) | KMT2APOLBTSHRSMN1; SMN2 | |
| SCHEMBL22003894 | 0.78 | — | — | |
| Sulfuric Acid SCHEMBL11764713 | 0.76 | HSD11B1 (0.44) | KMT2APOLBSMN1; SMN2 | |
| SCHEMBL22200207 | 0.75 | POLB (0.41) | KMT2AALDH1A1CYP2D6POLBMAPK1 | |
| SCHEMBL12887999 | 0.75 | GAA (0.61) | KMT2AALDH1A1POLBHTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104193725-B | Organic compound | 诺华股份有限公司 | 2016-11-16 | — | — | CN | disclosed |
| US-6194438-B1 | ANTITUMOR AGENTS; ANTICANCER AGENTS; FARNESYL-PROTEIN TRANSFERASE INHIBITOR | PFIZER INC. | 2001-02-27 | — | — | US | disclosed |
| EP-1006113-A1 | Derivatives of 2-(2-oxo-ethylidene)-imidazolidin-4-one and their use to inhibit abnormal cell growth | Pfizer Products Inc. (US) | 2000-06-07 | — | — | EP | disclosed |