Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 11/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
| ▸ | PREP | P48147 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.32 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.32 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3453171 | 0.76 | PREP (0.41) | GPR119HRH3PREPMAPT | |
| SCHEMBL30630491 | 0.71 | SMN1; SMN2 (0.39) | HRH3PREPPTPN2PTPN1PTPN6 | |
| SCHEMBL30191761 | 0.69 | TP53 (0.36) | GPR119HRH3PREP | |
| SCHEMBL6749271 | 0.67 | GPR119 (0.61) | GPR119KDM4EMAPTTHRBPTPN2 | |
| SCHEMBL22955094 | 0.66 | GPR119 (0.59) | GPR119KDM4EMAPTTHRBPTPN2 | |
| SCHEMBL27032710 | 0.65 | NR1H2 (0.48) | GPR119KDM4EMAPTTHRB | |
| SCHEMBL12324578 | 0.65 | NR1H2 (0.51) | GPR119KDM4EMAPTTHRBPTPN2 | |
| SCHEMBL5937854 | 0.65 | NR1H2 (0.51) | GPR119KDM4EMAPTTHRBPTPN2 | |
| SCHEMBL12323280 | 0.65 | NR1H2 (0.51) | GPR119KDM4EMAPTTHRBPTPN2 | |
| SCHEMBL18306619 | 0.65 | NR1H2 (0.51) | GPR119KDM4EMAPTTHRBPTPN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6194438-B1 | ANTITUMOR AGENTS; ANTICANCER AGENTS; FARNESYL-PROTEIN TRANSFERASE INHIBITOR | PFIZER INC. | 2001-02-27 | — | — | US | disclosed |