Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 2/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.39 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.39 |
| ▸ | SNCA | P37840 | 1/20 | 0.37 |
| ▸ | GUSB | P08236 | 1/20 | 0.37 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.36 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7911734 | 0.90 | PDE4D (0.44) | PDE4DPDE4BSNCAGUSB | |
| SCHEMBL15906153 | 0.88 | PDE4B (0.38) | PDE4DPDE4BCALM1GUSBNR3C1 | |
| SCHEMBL3789377 | 0.87 | PDE4D (0.39) | PDE4DPDE4BCALM1NR3C1 | |
| SCHEMBL13578452 | 0.84 | PDE4D (0.37) | PDE4DPDE4BCALM1SNCACNR2 | |
| SCHEMBL4326850 | 0.84 | TAAR1 (0.47) | PDE4DPDE4BSNCA | |
| SCHEMBL3790939 | 0.84 | CYP19A1 (0.40) | PDE4DPDE4B | |
| SCHEMBL3791461 | 0.83 | PDE4D (0.44) | PDE4DPDE4BSNCA | |
| SCHEMBL3467080 | 0.83 | PDE4B (0.42) | PDE4DPDE4BSNCANR3C1 | |
| SCHEMBL7902765 | 0.83 | PDE4B (0.39) | PDE4DPDE4B | |
| SCHEMBL7918181 | 0.82 | PDE4D (0.46) | PDE4DPDE4BSNCACNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010059838-A2 | PDE4 INHIBITORS SELECTIVE FOR THE LONG FORM OF PDE4 FOR TREATING INFLAMMATION AND AVOIDING SIDE EFFECTS | DECODE GENETICS EHF (IS) | 2010-05-27 | — | — | WO | disclosed |